23578-45-2Relevant articles and documents
Mineralization of synthetic polymer scaffolds: A bottom-up approach for the development of artificial bone
Song, Jie,Malathong, Viengkham,Bertozzi, Carolyn R.
, p. 3366 - 3372 (2005)
The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Cross-linked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to template the formation of hydroxyapatite. Strong adhesion between the organic and inorganic materials was achieved for hydrogels functionalized with either carboxylate or hydroxy ligands. The mineral-nucleating potential of hydroxyl groups identified here broadens the design parameters for synthetic bonelike composites and suggests a potential role for hydroxylated collagen proteins in bone mineralization.
Improving the Strategy and Performance of Molecularly Imprinted Polymers Using Cross-Linking Functional Monomers
Sibrian-Vazquez, Martha,Spivak, David A.
, p. 9604 - 9611 (2003)
A new strategy for monomer design has been investigated that combines interactive monomer functionality with a cross-linking format, giving as a result noncovalent molecularly imprinted polymers (MIPs) with improved performance. This strategy was explored under the premise that more functionality could be introduced without suffering performance losses due to reduced cross-linking. While this proved to be correct, equally important contributions to selectivity enhancement at the molecular level by conformation control and diastereomeric complexation were also discovered. Monomers derived from L-serine and L-aspartic acid were synthesized and used to prepare MIPs, with the best performance obtained for the MIP formulated with the serine-based cross-linker (N,O-bis-methacryloyl L-serine, 3), versus the aspartic-acid-based cross-linkers and the traditional methacrylic acid/ethylene glycol dimethacrylate (MAA/EGDMA) formulation. Quantitative structure selectivity relationship (QSSR) studies revealed that the improved performance of 3 was due to three key factors: (1) the cross-linking nature of this monomer; (2) control of conformational flexibility; (3) a strong influence of monomer chirality on enantioselectivity in MIPs.
A method of manufacturing a carboxylic acid monomer
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Paragraph 0044; 0049, (2018/10/19)
PROBLEM TO BE SOLVED: To provide a method for producing a carboxylic acid monomer with a slight halide content by using an easily available carboxylic acid compound and (meth)acrylic anhydride as raw materials. SOLUTION: A carboxylic acid monomer such as 2-(methacryloyloxy)acetic acid, 2-(methacryloyloxy)propionic acid or 2-(methacryloyloxy)-2-phenylacetic acid is produced by reaction between the corresponding carboxylic acid compound having OH, SH or NH2group and (meth)acrylic anhydride. In this case, an OH-bearing carboxylic acid compound to be used is preferable as a raw material. COPYRIGHT: (C)2012,JPOandINPIT
An organic silicon compound containing polymerized amide, due to their tropicalis tool and silicon-containing polymer
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Paragraph 0078; 0081, (2016/10/10)
There is provided a fast curing composition comprising an alpha, beta-unsaturated amido-containing organosilicon compound, useful in making water absorbing silicone-hydrogel films for biomedical devices, such as contact lens, and a process for producing these monomers. This invention also provides for hydrogels made from the alpha, beta-unsaturated amido-containing organosilicon compound described herein.
Synthesis and study of photochromic properties of copolymers based on functionalized chromenes
Grachev,Bakova,Makhonina,Yurieva,Aldoshin,Gorelik,Barachevskii
experimental part, p. 1469 - 1475 (2012/07/13)
Chromenes functionalized with methacryl groups were synthesized and involved into the radical polymerization to obtain copolymers with ethyl acrylate. Comparison of spectral kinetic characteristics of poly(methyl methacrylate) glasses containing chromenes and photochromic copolymers as additives led to a conclusion that incorporation of a photochromic compound as a part of a copolymer into the polymeric glass increases efficiency of photocoloration of photochromic compounds in the polymeric layer.
Water soluble polymers containing amino acid residues for dental restoratives
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, (2008/06/13)
Glass ionomer cements for dental restoratives with improved physical properties are produced by the present invention. Acryloyl and methacryloyl derivatives of amino acids are used in the invention to copolymerize with acrylic acid, methacrylic acid or various acrylic acid-comonomer mixtures to produce water soluble polycarboxylic acids.
Preparation and Enzymatic Hydrolysis of Polymers Anchoring Biphenyl-2-ol
Ishikawa, Tomomichi,Tanaka, Youji
, p. 1182 - 1185 (2007/10/02)
Polymers anchoring fungicidal biphenyl-2-ol(BPOL) were prepared by the polymerization and copolymerization of 2-biphenylyl methacrylate(BPMA) with various comonomers such as styrene, vinyl acetate, 2-hydroxyethyl methacrylate, N-methacryloylglycine, and N-methacryloyl-DL-alanine.The reactivity ratios of BPMA with the comonomers were evaluated.The α-chymotrypsin-catalyzed hydrolysis of the polymers was also studied.The release of BPOL from the polymers was represented by means of the Michaelis constant Km and the catalytic-rate constant kcat.The BPMA homopolymer gave higher Km and kcat values than the copolymers, and the copoly mers with a higher content of substrate units underwent cleavage more readily.It was found that the hydrolysis of the polymeric substrates is affected by the structure and character of the comonomer rather than the arrangement order of the repeating monomer units in the polymer sequence.
Enzymes immobilisees. 14 : Immobilisation de la chymotrypsine prealablement protegee par un inhibiteur macromoleculaire synthetique
Brown, Eric,Loriot, Michel
, p. 481 - 489 (2007/10/02)
A new water-soluble acrylic copolymer 13, with spacer-arms bearing N-(4-phenylbutyl)amido groups, was sythesized and was efficiently used to protect α-chymotrypsin during immobilization of the latter on Acaprosuc, an insoluble cross-linked polyacrylic gel whose side-chains end with reactive N-siccinimidyl ester groups.The insoluble chymotrypsin/Acaprosuc conjugates prepared in the presence of the polyinhibitor 13 were twice as active towards heamoglobin, and 2 to 4 times as active towards ATEE, as the corresponding conjugates prepared in the absence of the polyinhibitor 13.These results represent a generalization of the enzyme protection/immobilization/deprotection method which was developed in our laboratory some years ago in the particular case of trypsin.
N-Acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring
Gregersen,Keiding,Kolvraa
, p. 439 - 443 (2007/10/05)
Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each n-acylglycine as the N,O-bis(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.