23586-96-1

Basic information

• Product Name: 3-Pyridinemethanamine,5-fluoro-(9CI)
• Synonyms: 3-Pyridinemethanamine,5-fluoro-(9CI);3-Aminomethyl-5-fluoropyridine;(5-Fluoropyridin-3-yl)methylamine;3-Aminomethyl-5-fluoropyridine ,96%;3-Fluor-5-(aminomethyl)py...;3-Fluor-5-(aMinoMethyl)pyridine;5-fluoro-3-PyridineMethanaMine;3-Pyridinemethanamine,5-fluoro-
• CAS NO: 23586-96-1
• Molecular Formula: C₆H₇FN₂
• Molecular Weight: 126.133
• Product Categories: PYRIDINE;Building Blocks
• Mol File: 23586-96-1.mol

Chemical Properties

• Boiling Point: 194.6ºC at 760 mmHg
• Flash Point: 71.5ºC
• Appearance: /
• Density: 1.18g/cm3
• Vapor Pressure: 0.438mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.73±0.29(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanamine,5-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanamine,5-fluoro-(9CI)(23586-96-1)
• EPA Substance Registry System: 3-Pyridinemethanamine,5-fluoro-(9CI)(23586-96-1)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 23586-96-1(Hazardous Substances Data)

Usage

Uses

Used in Research and Chemical Processes:
3-Pyridinemethanamine,5-fluoro-(9CI) is used as a research chemical for studying its properties and potential applications. It serves as a building block or intermediate in the synthesis of more complex molecules and compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Pyridinemethanamine,5-fluoro-(9CI) is used as a precursor or intermediate in the development of new drugs. Its unique structure may contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
3-Pyridinemethanamine,5-fluoro-(9CI) may be used as a starting material or component in the synthesis of agrochemicals, such as pesticides and herbicides. Its potential applications in this field are still under investigation.
Used in Materials Science:
3-Pyridinemethanamine,5-fluoro-(9CI) could be employed in materials science for the development of new materials with specific properties, such as conductivity, magnetism, or catalytic activity. Its role in this industry is currently being explored.

InChI:InChI=1/C6H7FN2/c7-6-1-5(2-8)3-9-4-6/h1,3-4H,2,8H2

Upstream product

• 696-42-4 5-fluoropyridine-3-carbonitrile 
• 82671-02-1 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile 

Downstream Products

• 1439358-03-8 C₁₉H₁₆FN₃O₃S 
• 1363145-01-0 3-[(5-fluoropyridin-3-yl)methyl]-1-[4-(piperidine-1-sulfonyl)phenyl]urea 

Relevant articles and documents

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors

Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small molecules that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC), two important targets of cancer metabolism and epigenetics, respectively. Through iterative structure-based drug design, chemical synthesis, and biological assays, a highly potent dual NAMPT and HDAC inhibitor was successfully identified. Compound 35 possessed excellent and balanced activities against both NAMPT (IC50 = 31 nM) and HDAC1 (IC50 = 55 nM). It could effectively induce cell apoptosis and autophagy and ultimately led to cell death. Importantly, compound 35 showed excellent in vivo antitumor efficacy in the HCT116 xenograft model. This proof-of-concept study demonstrates the feasibility of discovering an inhibitor targeting cancer metabolism and epigenetics and provides an efficient strategy for multitarget antitumor drug discovery.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.