82671-02-1

Basic information

• Product Name: 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
• Synonyms: 2,6-Dichloro-3-cyano-5-fluoropyridine, 2,6-Dichloro-5-fluoro-3-nicotinonitrile;2,6-Dichloro-5-fluor;2,6-Dichloro-5-fluoronicotinonitrile 97%;2,6-dichloro-5-fluoropyridine-3-carbonitrile;6-Dichloro-3-cyano-5-fluoropyridine;2,6-Dichloro-5-fluoro-3-nicotinonitrile;3-Cyano-2,6-dichloro-5-fluoropyridine, 2,6-Dichloro-5-fluoropyridine-3-carbonitrile;3-Pyridinecarbonitrile,2,6-dichloro-5-fluoro-
• CAS NO: 82671-02-1
• Molecular Formula: C₆HCl₂FN₂
• Molecular Weight: 190.99
• EINECS: 1533716-785-6
• Product Categories: Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;blocks;FluoroCompounds;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines
• Mol File: 82671-02-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 89-91 °C(lit.)
• Boiling Point: 267.8 °C at 760 mmHg
• Flash Point: 115.8 °C
• Appearance: Light yellow/Crystalline Powder
• Density: 1.6175 (estimate)
• Vapor Pressure: 4.77E-05mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: -6.91±0.10(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile(82671-02-1)
• EPA Substance Registry System: 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile(82671-02-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 82671-02-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

General Description

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile is a pyridine derivative. It is a fluorinated heterocyclic building block used in chemical synthesis.

InChI:InChI=1/C6H2Cl2FNO2/c7-4-2(6(11)12)1-3(9)5(8)10-4/h1H,(H,11,12)

Upstream product

• 113237-18-6 5-fluoro-2,6-dihydroxynicotinonitrile 
• 107-06-2 1,2-dichloro-ethane 
• 75993-41-8 5-fluoro-2,6-dihydroxynicotinamide 

Downstream Products

• 870065-73-9 2,5,6-trifluoropyridine-3-carbonitrile 
• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 1422207-25-7 2-chloro-5-fluoro-6-(1-trityl-1H-pyrazolo[3,4-b]pyridin-3-yl)nicotinonitrile 
• 1361570-65-1 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-ol 
• 1361570-66-2 3-(4-chloro-5-nitropyrimidin-2-yl)-5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine 
• 1361570-67-3 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidin-4-amine 
• 1361570-68-4 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5-diamine 
• 1361569-39-2 6-amino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(2,2,2-trifluoroethyl)-7,9-dihydro-8H-purin-8-one 
• 1361569-72-3 5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine 
• 1361570-04-8 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-6-iodo-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one 
• 1361570-05-9 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7-(2,2,2-trifluoro ethyl)-7,9-dihydro-8H-purin-8-one 
• 1403745-37-8 3-[5-Fluoro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,7-dimethyl-5-{[2-(trimethylsilyl)ethoxy]methyl}-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one 
• 1403745-36-7 3-[5-Fluoro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one 
• 1403745-35-6 Methyl 2-{3-[5-fluoro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-hydroxy-1,2,4-triazin-6-yl}-2-methylpropanoate 

Relevant articles and documents

Process for the preparation of nicotinic acids

The present invention relates to an improved process for the preparation of nicotinic acids represented by the following structural formula (I): STR1 which are prepared by reacting a nicotinic amide compound having the formula: STR2 under acidic conditions with a nitrite salt. In the process of the invention have the groups R1, R2, and R3, in the compounds are independently selected from the group consisting of hydrogen, and halogen atoms and R4 is selected from the group consisting of hydrogen, lower alkyl and aryl. The process provides the nicotinic acid compounds in improved yields.

Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives

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