- PREPARATION OF DELMOPINOL
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It comprises a process for the production of delmopinol or a pharmaceutically acceptable salt and/or a solvate thereof, by subjecting the compound of formula (II) where R1 and R2 are the same or different, independently selected from the group consisting of H, (C1-C6) alkyl or, alternatively, R1 and R2 form, together with the carbon atom to which they are attached, a (C5-C6) cycloalkyl radical; and R3 is a radical selected from the group consisting of CF3, (C1-C4) alkyl, phenyl, and phenyl mono- ordisubstituted by a radical selected from the group consisting of (C1-C4)-alkyl, halogen and nitro to a deprotection and cyclisation reaction. The process is useful to prepare delmopinol or its salts on an industrial scale. The compound of formula (II) is new and also forms part of the present invention, as well as its preparation process and other new intermediates of said preparation process. .
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Page/Page column 12
(2008/06/13)
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- 2-Aminoethanols in Transacetalization Reactions
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Symmetric and mixed nitrogen-containing acetals and enol ethers were synthesized in an overall yield of 46-63% by reactions of N,N- dialkylaminoethanols with diethyl acetals derived from cyclohexanone, cyclopentanone, and acetophenone.
- Kukharev,Stankevich,Kukhareva
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p. 622 - 624
(2007/10/03)
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