- Studies on pyrazine derivatives. XLIX. Synthesis and antibacterial activity of 6-methoxypyrazine-2-carboxylic acid hydrazide derivatives
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The new 6-methoxy-pyrazine derivatives have been synthesized. 6-Methoxy-pyrazine-2-carboxylic acid hydrazide was used as an initial material to obtain mono- and dithioester of hydrazinecarbodithioic acid (2 and 3). Compound (2) in reaction with ethanolamine gave triazole derivative (8) with β-hydoxyethyl substituent in 4-position and hydroxyl group in 6-position of pyrazine ring. Dithioester (3) in a reaction with morpholine cyclized to 1,3,4-oxadiazole (11). The same substrate with alkyldiamines gave the few following derivatives: 1,3-diazacycloalkane derivatives (9 and 10), S-methyl-1,3,4-oxadiazole derivative (12) and 1,2,4-triazoletetrahydropyrimidine (13). The compounds obtained were tested in vitro for their activity towards pathogenic strains of anaerobic and aerobic bacteria. Derivative (9) was the most active against both types of tested strains.{A figure is presented}. 6-Methoxypyrazine-2-carboxylic Acid Hydrazide Hydrazinecarbodithioic Acid Ester Acid Ester 1,3,4-Oxadiazolethiol 1,2,4-Triazolethione.
- Gobis, Katarzyna,Foks, Henryk,Zuralska, Aleksandra,Kedzia, Anna
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- Pyrazinoic acid esters as anti-mycobacterium avium agents
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Compounds of formula II STR1 wherein R1 is a hydrocarbon, halogenated hydrocarbon, polyether, substituted phenyl, substituted benzyl or alkylamine; and R2, R3 and R4 are hydrogen, lower alkyl, halogen, haloalkyl, alkoxy and similar substituents are disclosed. The compounds are useful in the treatment of M. avium. Methods and compositions utilizing novel as well as known compounds are disclosed.
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