- 1-ACRYLOYLIMIDAZOLIDINE-2-ONE COMPOUND
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To provide a compound that is expected to be applied to cell culture materials, temperature-responsive polymer materials and the like.SOLUTION: The present invention relates to a 1-acryloylimidazolidine-2-one compound represented by formula (1) (where R1a is a hydrogen atom, a C1 to 4 alkyl group, a benzyl group or an oxyalkyl group represented by formula (2). R2a is a hydrogen atom or a C1 to 4 alkyl group. R3a is a hydrogen atom or a methyl group).SELECTED DRAWING: None
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Paragraph 0065-0067
(2021/03/03)
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- Silver-Catalyzed, N-Formylation of Amines Using Glycol Ethers
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A silver-catalyzed protocol was found to afford the N-formylation of amines in moderate-to-good yields. Ethylene glycol-derived, oligomeric ethers were found to function as the formylating agent, with 1,4-dioxane affording the best results. This reaction does not require the use of stoichiometric activating reagents, and avoids the use of explosive reagents or toxic gases, such as CO, as the C1 synthon. Mechanistic studies indicate a single-electron transfer-based pathway. This work highlights the ability of silver to participate in unexpected reaction pathways.
- King, Bradley H.,Wang, Michelle L.,Jesse, Kate A.,Kaur, Guneet,Tran, Brianna,Walser-Kuntz, Ryan,Iafe, Robert G.,Wenzel, Anna G.
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p. 13256 - 13263
(2020/11/26)
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- [11C]Carbonyl Difluoride—a New and Highly Efficient [11C]Carbonyl Group Transfer Agent
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Herein, the synthesis and use of [11C]carbonyl difluoride for labeling heterocycles with [11C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [11C]carbon monoxide into [
- Jakobsson, Jimmy E.,Lu, Shuiyu,Pike, Victor W.,Telu, Sanjay
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supporting information
p. 7256 - 7260
(2020/03/13)
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- Visible-Light-Mediated Liberation and In Situ Conversion of Fluorophosgene
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The first example for the photocatalytic generation of a highly electrophilic intermediate that is not based on radical reactivity is reported. The single-electron reduction of bench-stable and commercially available 4-(trifluoromethoxy)benzonitrile by an organic photosensitizer leads to its fragmentation into fluorophosgene and benzonitrile. The in situ generated fluorophosgene was used for the preparation of carbonates, carbamates, and urea derivatives in moderate to excellent yields via an intramolecular cyclization reaction. Transient spectroscopic investigations suggest the formation of a catalyst charge-transfer complex-dimer as the catalytic active species. Fluorophosgene as a highly reactive intermediate, was indirectly detected via its next downstream carbonyl fluoride intermediate by NMR. Furthermore, detailed NMR analyses provided a comprehensive reaction mechanism including a water dependent off-cycle equilibrium.
- Petzold, Daniel,Nitschke, Philipp,Brandl, Fabian,Scheidler, Veronica,Dick, Bernhard,Gschwind, Ruth M.,K?nig, Burkhard
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supporting information
p. 361 - 366
(2018/11/23)
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- 3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives
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A versatile synthesis of 1,4-benzodiazepine derivatives through the reaction of various 3-(trifluoromethanesulfonyloxy)benzynes with N -(p -toluenesulfonyl)imidazolidin-2-ones is reported. This reaction system provides a 1,4-benzodiazepine bearing a trifluoromethanesulfonyloxy group as a single regioisomer among the four possible regioisomers.
- Kaneko, Hideki,Ikawa, Takashi,Yamamoto, Yuta,Arulmozhiraja, Sundaram,Tokiwa, Hiroaki,Akai, Shuji
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supporting information
p. 943 - 948
(2018/02/26)
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- AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION
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This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.
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Page/Page column 325-326
(2017/12/01)
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- Coenzyme-inspired chemistry 1: The C-2 alkylation of 4,5-dihydroimidazoles
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Alkylation of 4,5-dihydroimidazoles at C-2 is accomplished using a double umpolung of the reactivity of that position, via sulfenylation of a nucleophilic C-2 lithio-species and substitution using an alkyl nucleophile. Arylation via unexpected sulfide con
- Jones, Raymond C.F.,Nichols, John R.
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p. 4114 - 4119
(2013/06/27)
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- Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
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The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1
- Thanigaimalai,Lee, Ki-Cheul,Bang, Seong-Cheol,Lee, Jee-Hyun,Yun, Cheong-Yong,Roh, Eunmiri,Hwang, Bang-Yeon,Kim, Youngsoo,Jung, Sang-Hun
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experimental part
p. 1135 - 1142
(2010/04/24)
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- 2-IMIDAZOLONE AND 2-IMIDAZOLIDINONE HETEROCYCLIC INHIBITORS OF TYROSINE PHOSPHATASES
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Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. The compounds for use in the compositions and methods provided herein have formulae (I) Protein tyrosine hosaphatase, including PTB-1B, mediated diseases and disorders include diabetes including Type 1 and Type 2 diabetes (and associated complications such as hypertension, ischemic diseases of the large and small blood vessels, blindness, circulatory problems, kidney failure and atherosclerosis), syndrome X, methabolic syndrome, glucose intolerance, insulin resistance, obesity, cancer, neurodegenerative diseases.
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Page/Page column 74-75
(2008/06/13)
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- Syntheses of oxazolidinone, imidazolidinone and thiazolidinone derivatives using a polymer-supported diphenylphosphoryl azide
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By using a polymer-supported diphenylphosphoryl azide (PS-DPPA), oxazolidinone, imidazolidinone and thiazolidinone derivatives were successfully prepared from carboxylic acids bearing different reactive functional groups in the β position, such as alcohols, thiols, primary or secondary amines. The desired compounds were obtained in good yields via Curtius rearrangement and subsequent intramolecular cyclization.
- Lu, Yuhua,Taylor, Richard T.
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p. 869 - 876
(2007/10/03)
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- Pyrrolidine derivatives and their use as chymase inhibitor
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Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R1 is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, fury
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- Tetrahydrofolate coenzyme models: Imidazolines as nucleophilic C1-transfer reagents
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1-Benzyl-2-imidazoline is deprotonated at C-2 and alkylated by a sulphenylation-substitution sequence (to complete a formal C1-transfer), whereas arylation occurs by an unusual sulphenylation-sulphide contraction pathway.
- Jones,Nichols
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p. 1767 - 1770
(2007/10/02)
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