2385-38-8

Usage

Uses

Used in Organic Synthesis:
1-Benzyl-2-imidazolidinone (SALTDATA: FREE) is used as a synthetic building block for the creation of various organic compounds. Its unique structure allows it to be a versatile component in the synthesis of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-benzyl-2-imidazolidinone (SALTDATA: FREE) is used as an intermediate in the synthesis of various drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties of the final product, making it a valuable asset in drug development.
Used in Agrochemical Industry:
1-Benzyl-2-imidazolidinone (SALTDATA: FREE) is also utilized in the agrochemical industry for the synthesis of pesticides, herbicides, and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness and selectivity, leading to improved agricultural productivity and crop protection.
Used in Specialty Chemicals:
In the specialty chemicals sector, 1-benzyl-2-imidazolidinone (SALTDATA: FREE) is employed in the development of various high-value products, such as dyes, fragrances, and additives. Its unique chemical properties make it an essential component in the synthesis of these specialty chemicals, contributing to their performance and functionality.

InChI:InChI=1/C10H12N2O/c13-10-11-6-7-12(10)8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,11,13)

Upstream product

• 61764-86-1 1-benzyl-4,5-dihydroimidazole 
• 103-19-5 di(p-tolyl) disulfide 
• 882-33-7 diphenyldisulfane 
• 497-25-6 dimethylenecyclourethane 
• 100-46-9 benzylamine 
• 5426-62-0 N-benzyl-β-alanine 
• 4152-09-4 N-benzylethylenediamine 
• 120-93-4 imidazolidone 
• 100-39-0 benzyl bromide 
• 332-25-2 4-(trifluoromethoxy)benzonitrile 
• 57-13-6 urea 
• 530-62-1 1,1'-carbonyldiimidazole 
• 174799-52-1 tert-butyl {2-[benzylamino]ethyl}carbamate 
• 67909-04-0 1-benzyl-1,3-dihydro-2H-imidazol-2-one 

Downstream Products

• 123566-44-9 1-benzylimidazolidine-2-thione 
• 1394836-12-4 1-(2-furoyl)-3-benzyl-imidazolidin-2-one 
• 1394836-10-2 1-[(E)-(3-phenyl)acryloyl]-3-benzyl-imidazolidin-2-one 
• 1394836-11-3 1-[(2E, 4E)-hexadienoyl]-3-benzyl-imidazolidin-2-one 
• 1018331-31-1 C₁₉H₂₁IN₂O₃ 
• 1163250-30-3 C₁₉H₂₁BrN₂O₃ 
• 581102-66-1 tert-butyl 2-(2oxo-3-benzylimidazolidinyl)acetate 
• 901386-31-0 {[4-(3-benzyl-2-oxo-imidazolidin-1-ylmethyl)-2-bromo-phenyl]-difluoro-methyl}-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

1-ACRYLOYLIMIDAZOLIDINE-2-ONE COMPOUND

To provide a compound that is expected to be applied to cell culture materials, temperature-responsive polymer materials and the like.SOLUTION: The present invention relates to a 1-acryloylimidazolidine-2-one compound represented by formula (1) (where R1a is a hydrogen atom, a C1 to 4 alkyl group, a benzyl group or an oxyalkyl group represented by formula (2). R2a is a hydrogen atom or a C1 to 4 alkyl group. R3a is a hydrogen atom or a methyl group).SELECTED DRAWING: None

Silver-Catalyzed, N-Formylation of Amines Using Glycol Ethers

A silver-catalyzed protocol was found to afford the N-formylation of amines in moderate-to-good yields. Ethylene glycol-derived, oligomeric ethers were found to function as the formylating agent, with 1,4-dioxane affording the best results. This reaction does not require the use of stoichiometric activating reagents, and avoids the use of explosive reagents or toxic gases, such as CO, as the C1 synthon. Mechanistic studies indicate a single-electron transfer-based pathway. This work highlights the ability of silver to participate in unexpected reaction pathways.

[11C]Carbonyl Difluoride—a New and Highly Efficient [11C]Carbonyl Group Transfer Agent

Herein, the synthesis and use of [11C]carbonyl difluoride for labeling heterocycles with [11C]carbonyl groups in high molar activity is described. A very mild single-pass gas-phase conversion of [11C]carbon monoxide into [

Visible-Light-Mediated Liberation and In Situ Conversion of Fluorophosgene

The first example for the photocatalytic generation of a highly electrophilic intermediate that is not based on radical reactivity is reported. The single-electron reduction of bench-stable and commercially available 4-(trifluoromethoxy)benzonitrile by an organic photosensitizer leads to its fragmentation into fluorophosgene and benzonitrile. The in situ generated fluorophosgene was used for the preparation of carbonates, carbamates, and urea derivatives in moderate to excellent yields via an intramolecular cyclization reaction. Transient spectroscopic investigations suggest the formation of a catalyst charge-transfer complex-dimer as the catalytic active species. Fluorophosgene as a highly reactive intermediate, was indirectly detected via its next downstream carbonyl fluoride intermediate by NMR. Furthermore, detailed NMR analyses provided a comprehensive reaction mechanism including a water dependent off-cycle equilibrium.

3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives

A versatile synthesis of 1,4-benzodiazepine derivatives through the reaction of various 3-(trifluoromethanesulfonyloxy)benzynes with N -(p -toluenesulfonyl)imidazolidin-2-ones is reported. This reaction system provides a 1,4-benzodiazepine bearing a trifluoromethanesulfonyloxy group as a single regioisomer among the four possible regioisomers.

AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION

This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Coenzyme-inspired chemistry 1: The C-2 alkylation of 4,5-dihydroimidazoles

Alkylation of 4,5-dihydroimidazoles at C-2 is accomplished using a double umpolung of the reactivity of that position, via sulfenylation of a nucleophilic C-2 lithio-species and substitution using an alkyl nucleophile. Arylation via unexpected sulfide con

Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis

The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1

2-IMIDAZOLONE AND 2-IMIDAZOLIDINONE HETEROCYCLIC INHIBITORS OF TYROSINE PHOSPHATASES

Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. The compounds for use in the compositions and methods provided herein have formulae (I) Protein tyrosine hosaphatase, including PTB-1B, mediated diseases and disorders include diabetes including Type 1 and Type 2 diabetes (and associated complications such as hypertension, ischemic diseases of the large and small blood vessels, blindness, circulatory problems, kidney failure and atherosclerosis), syndrome X, methabolic syndrome, glucose intolerance, insulin resistance, obesity, cancer, neurodegenerative diseases.

Syntheses of oxazolidinone, imidazolidinone and thiazolidinone derivatives using a polymer-supported diphenylphosphoryl azide

By using a polymer-supported diphenylphosphoryl azide (PS-DPPA), oxazolidinone, imidazolidinone and thiazolidinone derivatives were successfully prepared from carboxylic acids bearing different reactive functional groups in the β position, such as alcohols, thiols, primary or secondary amines. The desired compounds were obtained in good yields via Curtius rearrangement and subsequent intramolecular cyclization.