23884-44-8Relevant articles and documents
Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors
Majmudar, Jaimeen D.,Hahne, Kalub,Hrycyna, Christine A.,Gibbs, Richard A.
supporting information; experimental part, p. 2616 - 2620 (2011/06/20)
Human isoprenylcysteine carboxyl methyltransferase (hIcmt) is a promising anticancer target as it is important for the post-translational modification of oncogenic Ras proteins. We herein report the synthesis and biochemical activity of 41 farnesyl-cystei