239088-19-8

Basic information

• Product Name: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester
• Synonyms: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester
• CAS NO: 239088-19-8
• Molecular Formula: C₂₇H₃₇NO₃
• Molecular Weight: 424
• Product Categories: Amines;Aromatics;Amines, Aromatics
• Mol File: 239088-19-8.mol

Chemical Properties

• Boiling Point: 568.2±29.0 °C(Predicted)
• Appearance: /
• Density: 1.079±0.06 g/cm3(Predicted)
• PKA: 14.59±0.10(Predicted)
• CAS DataBase Reference: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(239088-19-8)
• EPA Substance Registry System: Decyl(2-hydroxyethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester(239088-19-8)

Safety Data

• Hazardous Substances Data: 239088-19-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Decyl(2-hydroxyethyl)-carbamic Acid 9H-Fluoren-9-ylMethyl Ester is used as a chemical intermediate for the preparation of vancomycin-related antibacterial agents, which are essential in combating various bacterial infections, particularly those caused by antibiotic-resistant strains. Its role in the synthesis process is crucial for the development of new and effective treatments in the field of medicine.

Upstream product

• 41233-29-8 methanesulfonic acid decyl ester 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 15196-28-8 2-(n-Decylamino)ethanol 
• 112-30-1 1-Decanol 

Downstream Products

• 239088-22-3 N-decyl-N-(2-oxoethyl)carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Synthesis method of special-pulling universal intermediate (by machine translation)

To the invention, 9 - 2, 2, 6 tetramethylpiperidine oxide (TEMPO) is used as an oxidizing agent, the reaction temperature 6 - is lower, Fmoc-Cl is protected and oxidized to obtain N - (0 °C fluorenylmethoxycarbonyl) decyl aminoacetaldehyde. TEMPO oxidation is simple, the reaction temperature is mild, pH value and reaction temperature of the reaction liquid are controlled. (by machine translation)

VANCOMYCIN DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Provided are a class of vancomycin derivatives with a structure as shown in the general formula below and pharmaceutically acceptable salts thereof, a preparation method, a pharmaceutical composition containing the compound thereof, and the use of these compounds in preparing drugs for treating and/or preventing bacterial infection diseases, in particular drugs for treating infection diseases caused by Gram-positive bacteria.

Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci

Lipophilic substitution on vancomycin is an effective strategy for the development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interactions. However, hydrophobic structures usually lead to long elimination half-life and accumulative toxicity; therefore, hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their pharmacokinetic/pharmacodynamic properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the seventh-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive structure-activity relationship analysis. The optimal analogues indicated 128-1024-fold higher activity against methicillin-susceptible S. aureus, vancomycin-intermediate resistant S. aureus (VISA), and vancomycin-resistant Enterococci (VRE) compared with that of vancomycin. In vivo pharmacokinetics studies demonstrated the effective regulation of extra sugar motifs, which shortened the half-life and addressed concerns of accumulative toxicity of lipo-vancomycin. This work presents an effective strategy for lipo-vancomycin derivative design by introducing extra sugars, which leads to better antibiotic-like properties of enhanced efficacy, optimal pharmacokinetics, and lower toxicity.

Process for preparing glycopeptide derivatives

Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products.

Process for preparing glycopeptide phosphonate derivatives

Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.

Derivatives of glycopeptide antibacterial agents

Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.