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239101-33-8

Deferitrin is a tridentate oral chelator, specifically designed for the primary treatment of iron overload conditions that arise from transfusion therapy.

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  • 239101-33-8 Structure

  • Basic information

    1. Product Name: Deferitrin
    2. Synonyms: Deferitrin;Deferitrin (GT-56-252);4,5-Dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazol-4-(S)-carboxylic acid;GT 56-252
    3. CAS NO:239101-33-8
    4. Molecular Formula: C11H11NO4S
    5. Molecular Weight: 253.277
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 239101-33-8.mol

  • Chemical Properties

    1. Melting Point: 281-283℃ (decomposition)
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Deferitrin(CAS DataBase Reference)
    10. NIST Chemistry Reference: Deferitrin(239101-33-8)
    11. EPA Substance Registry System: Deferitrin(239101-33-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 239101-33-8(Hazardous Substances Data)

239101-33-8 Usage

Uses

Used in Medical Industry:
Deferitrin is used as a therapeutic agent for managing iron overload, a condition that can occur as a result of frequent blood transfusions. It helps in reducing the excess iron levels in the body, thereby mitigating the associated health risks and complications.

Check Digit Verification of cas no

The CAS Registry Mumber 239101-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,9,1,0 and 1 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 239101-33:
(8*2)+(7*3)+(6*9)+(5*1)+(4*0)+(3*1)+(2*3)+(1*3)=108
108 % 10 = 8
So 239101-33-8 is a valid CAS Registry Number.

239101-33-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2Z,4S)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-1,3-thiazolidine-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names 4'-Hydroxydesazadesferrithiocin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:239101-33-8 SDS

239101-33-8Relevant articles and documents

Synthesis of benzonitriles from substituted benzaldehyde

-

Page/Page column 4, (2008/06/13)

There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid crystal dopant, antipicornaviral agents, anti-inflammatory agents, anti-asthma agents, and fibringoen antagonists. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and diethers thereof, from 2,4-dihydroxybenzaldehyde or 2,4-dimethoxybenzaldehyde. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, 2,4-dihydroxybenzonitrile is condensed with (S)-2-methylcysteine.

Effects of C-4 stereochemistry and C-4' hydroxylation on the iron clearing efficiency and toxicity of desferrithiocin analogues

Bergeron, Raymond J.,Wiegand, Jan,McManis, James S.,McCosar, Bruce H.,Weimar, William R.,Brittenham, Gary M.,Smith, Richard E.

, p. 2432 - 2440 (2007/10/03)

Additional structure-activity studies of desferrithiocin analogues are carried out. The effects of stereochemistry at C-4 on the ligands' iron clearing efficiency are reviewed and assessed using the enantiomers 4,5- dihydro-2-(2,4-dihydroxyphenyl)thiazole-4(R)-carboxylic acid and 4,5-dihydro- 2-(2,4-dihydroxyphenyl)thiazole-4(S)-carboxylic acid. The utility of 4'- hydroxylation as a method of reducing the toxicity of desazadesferrithiocin analogues is also examined further with the synthesis and in vivo comparison of 4,5-dihydro-2-(2-hydroxyphenyl)-4-methylthiazole-4(S)-carboxylic acid, which is the natural product 4-methylaeruginoic acid, and 4,5-dihydro-2- (2,4-dihydroxyphenyl)-4-methylthiazole-4(S)-carboxylic acid. The stereochemistry at C-4 is shown to have a substantial effect on the iron clearing efficiency of desferrithiocin analogues, as does C-4'-hydroxylation on the toxicity profile. All of the compounds are evaluated in a bile-duct- cannulated rodent model to determine iron clearance efficiency and are carried forward to the iron-overloaded primate for iron clearing measurements. On the basis of the results of the present work, although 4,5- dihydro-2-(2,4-dihydroxyphenyl)thiazole-4(S)-carboxylic acid is still the most promising candidate for clinical evaluation, 4,5-dihydro-2-(2,4- dihydroxyphenyl)4-methylthiazole-4(S)-carboxylic acid (4'- hydroxydesazadesferrithiocin) also merits further preclinical assessment.

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