Deferitrin

Base Information

• Chemical Name: Deferitrin
• CAS No.: 239101-33-8
• Molecular Formula: C11H11NO4S
• Molecular Weight: 253.279
• Mol file: 239101-33-8.mol

Synonyms:4'-Hydroxydesazadesferrithiocin;GT 56-252;UNII-T69Y9LDN44;Deferitrin;

Chemical Property of Deferitrin

Chemical Property:

• Melting Point: 281-283℃ (decomposition)
• PSA: 115.42000
• LogP: 0.87010

Purity/Quality:

97% ^*data from raw suppliers

Deferitrin >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Deferitrin is a tridentate oral chelator intended for use in the primary treatment of iron overload resulting from transfusion therapy.

Technology Process of Deferitrin

There total 3 articles about Deferitrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

2,4-dihydroxybenzonitrile (64419-24-5) + (S)-α-methylcysteine hydrochloride → deferitrin (239101-33-8)

Guidance literature:

With triethylamine; In ethanol; for 20h; Heating / reflux;

Reference yield: 15.4%

4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazole-4(S)-carboxylic acid (627101-38-6) → deferitrin (239101-33-8)

Guidance literature:

Purification / work up; Resolution of racemate;

Reference yield:

2,4-dihydroxybenzonitrile (64419-24-5) + (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid (76045-30-2) → deferitrin (239101-33-8)

Guidance literature:

With hydrogenchloride; phosphate buffer; sodium hydrogencarbonate; Yield given; Multistep reaction; 1.) 100 deg C, 80 min, 2.) CH₃OH, 71 deg C, 3.5 d;

DOI:10.1021/jm990058s

upstream raw materials:

2,4-dihydroxybenzonitrile

(S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid

4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methylthiazole-4(S)-carboxylic acid

Downstream raw materials:

ethyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

isopropyl (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

(S)-4,5-dihydro-2-(2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl)-4-methyl-4-thiazolecarboxylic acid

ethyl (S)-4,5-dihydro-2-[2-hydroxy-4-[12-(tert-butoxycarbonylamino)-5,9-bis(tert-butoxycarbonyl)-5,9-diazadodecyloxy]phenyl]-4-methyl-4-thiazolecarboxylate