23922-04-5 Usage
Uses
Used in Pharmaceutical Industry:
2-METHYL-3,4,5,6,7,8-HEXAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-4-THIONE is used as a reactant in the synthesis and evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids. These compounds serve as potential inhibitors of human protein kinase CK2, which plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Inhibition of this enzyme may have therapeutic applications in treating various diseases, including cancer and inflammatory disorders.
Used in Organic Synthesis:
2-METHYL-3,4,5,6,7,8-HEXAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE-4-THIONE can be employed as a key intermediate in the synthesis of various heterocyclic compounds with potential applications in pharmaceuticals, agrochemicals, and materials science. Its unique structure allows for further functionalization and modification, enabling the development of novel compounds with improved properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 23922-04-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,9,2 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 23922-04:
(7*2)+(6*3)+(5*9)+(4*2)+(3*2)+(2*0)+(1*4)=95
95 % 10 = 5
So 23922-04-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2S2/c1-6-12-10(14)9-7-4-2-3-5-8(7)15-11(9)13-6/h2-5H2,1H3,(H,12,13,14)
23922-04-5Relevant articles and documents
Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin- 4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2
Golub, Andriy G.,Bdzhola, Volodymyr G.,Briukhovetska, Nadiia V.,Balanda, Anatoliy O.,Kukharenko, Olexander P.,Kotey, Igor M.,Ostrynska, Olga V.,Yarmoluk, Sergiy M.
scheme or table, p. 870 - 876 (2011/04/22)
A novel series of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids has been synthesized and tested in vitro towards human protein kinase CK2. It was revealed that the most active compounds inhibiting CK2 are 3-{[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid and 3-{[5-(4-ethoxyphenyl)thieno[2,3-d]pyrimidin-4-yl]thio}propanoic acid (IC 50 values are 0.1 μM and 0.125 μM, respectively). Structure-activity relationships of 28 tested thienopyrimidine derivatives have been studied and binding mode of this chemical class has been predicted. Evaluation of the inhibitors on seven protein kinases revealed considerable selectivity towards CK2.
