239463-89-9

Basic information

• Product Name: 4-CHLORO-6,8-DIFLUOROQUINOLINE
• Synonyms: BUTTPARK 30\09-66;4-CHLORO-6,8-DIFLUOROQUINOLINE;Quinoline, 4-chloro-6,8-difluoro-
• CAS NO: 239463-89-9
• Molecular Formula: C9H4ClF2N
• Molecular Weight: 199.58
• Mol File: 239463-89-9.mol

Chemical Properties

• Boiling Point: 256.9°C at 760 mmHg
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.455g/cm³
• Vapor Pressure: 0.0242mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-6,8-DIFLUOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6,8-DIFLUOROQUINOLINE(239463-89-9)
• EPA Substance Registry System: 4-CHLORO-6,8-DIFLUOROQUINOLINE(239463-89-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 239463-89-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6,8-difluoroquinoline is used as an intermediate in the synthesis of various pharmaceuticals for its potential pharmacological activities. Its unique structure allows for the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 4-chloro-6,8-difluoroquinoline serves as an intermediate in the synthesis of agrochemicals, contributing to the development of new and effective pesticides. Its pesticidal properties make it a valuable component in creating innovative solutions for crop protection and management.
Used in Medicinal Chemistry Research:
4-Chloro-6,8-difluoroquinoline is utilized in medicinal chemistry research for its antimicrobial and antiparasitic properties. Its unique structure and activity make it a valuable tool in the discovery and development of new therapeutic agents to combat various infectious diseases.
Overall, 4-chloro-6,8-difluoroquinoline is a versatile compound with significant applications in the pharmaceutical and agrochemical industries, as well as in medicinal chemistry research. Its unique properties and potential activities make it an essential component in the development of new and improved products for various applications.

InChI:InChI=1/C9H4ClF2N/c10-7-1-2-13-9-6(7)3-5(11)4-8(9)12/h1-4H

Upstream product

• 243448-16-0 4-hydroxy-6,8-difluoro-quinoline 
• 367-25-9 2,4-difluorophenylamine 
• 1384272-23-4 6,8-difluoroquinolin-4(1H)-one 
• 1071541-70-2 5-[(3,5-difluoro-phenylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 372-39-4 3,5-difluoroaniline 

Downstream Products

• 1384272-31-4 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(5-fluoro-2-methylphenyl)urea 
• 1384272-32-5 1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)urea 
• 1384272-33-6 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(4-isopropylphenyl)urea 
• 1384272-34-7 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(3,4-dimethylphenyl)urea 
• 1384272-25-6 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(2-(trifluoromethoxy)phenyl)urea 
• 1384272-26-7 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(4-(trifluoromethoxy)phenyl)urea 
• 1384272-27-8 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(2-(trifluoromethyl)phenyl)urea 
• 1384272-28-9 1-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)-3-(4-(trifluoromethyl)phenyl)urea 
• 1384272-30-3 1-(3-chloro-2-fluorophenyl)-3-(2-((6,8-difluoroquinolin-4-yl)amino)ethyl)urea 

Relevant articles and documents

Aurora Kinase Modulators and Method of Use

The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Synthesis, anti-inflammatory and antimicrobial evaluation of novel N1-(quinolin-4yl)ethane-1,2-diamine phenyl urea derivatives

A series of substituted N-(quinolin-4-yl)ethanediamine phenyl urea derivatives of biological interest were prepared by sequential quinoline synthesis, chlorination, and substitution reaction followed by reaction of resulting amine with different aryl isoc

AURORA KINASE MODULATORS AND METHOD OF USE

The present invention relates to chemical compounds having a general formula I {INSERT STRUCTURE HERE} wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.