372-39-4 Usage
Description
3,5-Difluoroaniline is a white to yellowish low melting solid that has been investigated for its in vitro nephrotoxic effects in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.
Uses
Used in Chemical Synthesis:
3,5-Difluoroaniline is used as a chemical intermediate for the preparation of 3,5-difluorodimethylaniline, which is an important compound in the synthesis of various pharmaceuticals and organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,5-difluoroaniline is used as a building block for the development of new drugs, particularly those targeting the kidney and renal system. Its nephrotoxic effects have been studied to better understand its potential applications and limitations in drug design.
Used in Research and Development:
3,5-Difluoroaniline is also utilized in research and development for the investigation of its chemical properties, reactivity, and potential applications in various fields, including material science and environmental chemistry.
Synthesis
Work on halogenated benzenes has also demonstrated the versatility of this
technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and
de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5-
difluoronitrobenzene giving 3,5-difluoroaniline.
Check Digit Verification of cas no
The CAS Registry Mumber 372-39-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 372-39:
(5*3)+(4*7)+(3*2)+(2*3)+(1*9)=64
64 % 10 = 4
So 372-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
372-39-4Relevant articles and documents
Gershon et al.
, p. 105 (1972)
Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air
Bao, Xuefei,Chen, Guoliang,Dong, Jinhua,Du, Fangyu,Li, Hui,Liang, Xinjie,Wu, Ying,Zhang, Yongsheng
supporting information, (2020/08/03)
L-(?)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95percent ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.
Preparation method of polyfluoroaniline
-
, (2018/08/03)
The invention relates to a preparation method of polyfluoroaniline, according to the method, the polyfluoroaniline is prepared by a two-step common reaction from polyfluorobenzene as a raw material, the method has the characteristics of low reaction temperature, small pressure, low cost, and the like, is suitable for industrial production application, and is convenient for large-scale production;the polyfluoroaniline product obtained by the method has less impurities and high product purity.