- DICYANSTYRYL BENZENE DERIVATIVES AND FLUORESCENT MATERIAL COMPRISING THE SAME
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The present invention refers to die [...] benzene derivatives represented by formula 1 are disclosed. The, head of the present invention die [...] benzene to yield fluorescent derivatives (Dicyanstyryl benzene) to minimize environmental pollution by reducing the drain diameter number fluorescent material can be [...] number can be improve. [Formula 1] (by machine translation)
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- Tunable photophysical properties of thiophene based chromophores: A conjoined experimental and theoretical investigation
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In this paper we report the synthesis and photophysical properties of six novel thiophene derivatives (ThD) with D-π-A structure. The subject of this work is three nitrophenyls (1) BT-Th-NO2 and three benzonitriles (2) BT-Th-CN, substituted at
- Popczyk, Anna,Cheret, Yohan,Grabarz, Anna,Hanczyc, Piotr,Fita, Piotr,El-Ghayoury, Abdelkrim,Sznitko, Lech,Mysliwiec, Jaroslaw,Sahraoui, Bouchta
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supporting information
p. 6728 - 6736
(2019/05/04)
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- Green synthesis method of 1,4-bis(2-cyanostyryl)benzene
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The invention discloses a green synthesis method of 1,4-bis(2-cyanostyryl)benzene, and belongs to the technical field of chemical synthesis. The green synthesis method comprises the following steps: adding excessive amount of triethyl phosphite and a solvent into a reactor under the normal pressure, heating, rapidly stirring an added dissolved cyanobenzylchloride solution, continuing to add the material, and conducting a thermal reaction to obtain a reactant; adding N,N-dimethylformamide (DMF) into the reactant, dissolving, stirring, respectively adding terephthalaldehyde and an alkali at equal molar weight, conducting a thermal reaction, cooling, regulating the PH value, cooling, centrifuging, refining with methyl alcohol, drying under the negative pressure, and pulverizing to obtain 1,4-bis(2-cyanostyryl)benzene; and centrifuging a mother solution, and distilling to obtain sodium diethylphosphate. The green synthesis method overcomes the defects of excessive phosphorus containing wastes, difficulty in separating and processing and the like, the production of sodium dihydrogen phosphate and other phosphorus containing wastes is greatly reduced, and sodium diethylphosphate having the industrial application value is achieved with the high yield.
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Page/Page column 3; 6; 7; 8
(2018/03/01)
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- NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS
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The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.
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Paragraph 00191
(2015/07/07)
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- Ligustrazine Derivatives. Part 4: Design, Synthesis, and Biological Evaluation of Novel Ligustrazine-based Stilbene Derivatives as Potential Cardiovascular Agents
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A series of novel stilbene derivatives containing ligustrazinyl moiety was designed, synthesized, and assayed for their protective effects on damaged endothelial cells. The results showed that most ligustrazinyl stilbene derivatives exhibited high protective effects on the human umbilical vascular endothelial cells (HUVECs) damaged by hydrogen peroxide in comparison with Ligustrazine. The stilbene derivatives A6, A9, A11, A21, A24, A25, and A27 exhibited high potency with low EC50 values ranged from 0.0249μm to 0.0898mm. Compound A27 displayed EC50 0.0249μm, which is 30000 times higher than that of Ligustrazine, presenting a most promising lead for further investigation. Structure-activity relationships were briefly discussed.
- Deng, Lijuan,Guo, Xiuli,Zhai, Li,Song, Yuning,Chen, Hongfei,Zhan, Peng,Wu, Jingde,Liu, Xinyong
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experimental part
p. 731 - 739
(2012/05/20)
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- Olefin-Oxazolines (OlefOx): Highly modular, easily tunable ligands for asymmetric catalysis
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Figure presented Foxy ligands: An efficient three-step synthesis allows the new highly modular family of olefin-oxazoline ligands (OlefOx; see picture) to be exploited in asymmetric catalysis. The ease of electronic and steric variation and the successful
- Hahn, Bjoern T.,Tewes, Friederike,Froehlich, Roland,Glorius, Frank
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supporting information; experimental part
p. 1143 - 1146
(2010/05/02)
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- Rh-catalyzed Negishi alkyl-aryl cross-coupling leading to α- or β-phosphoryl-substituted alkylarenes
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The catalytic cross-coupling between ArZnX and ICH2(CH 2)nP(O)(OEt)2 (n = 0-3) has been investigated to determine the utility of the Rh catalyst during the alkyl-aryl cross-coupling and to develop a new syntheti
- Takahashi, Hideki,Inagaki, Shinya,Yoshii, Naoko,Gao, Fuxing,Nishihara, Yasushi,Takagi, Kentaro
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supporting information; experimental part
p. 2794 - 2797
(2009/09/08)
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- Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity
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We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety
- Imamura, Shinichi,Ichikawa, Takashi,Nishikawa, Youichi,Kanzaki, Naoyuki,Takashima, Katsunori,Niwa, Shinichi,Iizawa, Yuji,Baba, Masanori,Sugihara, Yoshihiro
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p. 2784 - 2793
(2007/10/03)
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- Synthesis, structure and solvatochromism of the emission of cyano-substituted oligo(phenylenevinylene)s
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Strongly luminescent and highly soluble oligo(phenylenevinylene)s with five benzene rings and cyano groups in different positions of the terminal styrene units were prepared by means of Horner and Knoevenagel reactions. The substitution pattern - cyanide moieties on the vinyl or on the aromatic regions, together with the effect of auxochromic groups - has distinct influences on the electronic spectra, particularly on the fluorescence. Polar solvents induce red shifts and strongly reduce the fluorescence intensity of the vinyl-substituted oligomers. Cyano substitution increases the electron affinity of the oligomers; this effect is more pronounced for molecules with vinyl cyanides and can be altered by the presence of additional electron-donating or electron-withdrawing groups. The molecular structures of one oligomer bearing cyano groups on the vinylene segments and one with benzonitrile units have been resolved.
- Detert, Heiner,Schollmeyer, Dieter,Sugiono, Erli
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p. 2927 - 2938
(2007/10/03)
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- Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses
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The use of a compound of the formula I STR1 in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R1 and R2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R1 and R2 together form a cyclic diester, R3 and R4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
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