- PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
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The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.
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Paragraph 0612
(2016/07/27)
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- Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines
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Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2,2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.
- Kancharla, Papireddy,Reynolds, Kevin A.
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p. 8375 - 8385
(2013/09/02)
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- Pyrrolotriazine inhibitors of kinases
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The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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Page/Page column 22-23
(2008/06/13)
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- Novel Substituent Orientation in Reimer-Tiemann Reactions of Pyrrole-2-carboxylates
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Reimer-Tiemann formylation reactions (base/CHCl3) on 5-substituted pyrrole-2-carboxylates (1, 6, 8, 9, 11, and 13) afford 2-formylpyrroles (5, 7, 10, 12, and 14) in which the formyl group is situated in the position originally occupied by the carboxylate
- Smith, Kevin M.,Bobe, Frank W.,Minnetian, Ohannes M.,Hope, Hakon,Yanuck, Michael D.
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p. 790 - 792
(2007/10/02)
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- Metabolites of the Marine Sponge Laxosuberites sp.
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The marine sponge Laxosuberites sp. contained a mixture of four 5-alkylpyrrole-2-carboxaldehydes 1, (6'Z)-5-(12'-cyano-6'-dodecenyl)pyrrole-2-carboxaldehyde (2), and (6'Z)-5-(23'-cyano-23'-hydroxy-6'-tricosenyl)pyrrole-2-carboxaldehyde (3).The structures of the metabolites were determined by interpretation of spectral data and by chemical degradation.The cyanohydrin 3 is unusually stable to normal isolation and storage procedures.
- Stierle, Donald B.,Faulkner, John D.
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p. 4980 - 4982
(2007/10/02)
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