24014-18-4

Basic information

• Product Name: 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE
• Synonyms: 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE
• CAS NO: 24014-18-4
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• Mol File: 24014-18-4.mol

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 227.4°C at 760 mmHg
• Flash Point: 96.7°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.0775mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.50±0.50(Predicted)
• CAS DataBase Reference: 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE(24014-18-4)
• EPA Substance Registry System: 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE(24014-18-4)

Safety Data

• Hazardous Substances Data: 24014-18-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-METHYL-1H-PYRROLE-2-CARBALDEHYDE is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse molecular entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE is utilized as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. Its role in these applications is crucial for enhancing crop protection and improving agricultural productivity.
Used in Flavor and Fragrance Industry:
3-METHYL-1H-PYRROLE-2-CARBALDEHYDE is employed as a flavoring agent in the food and beverage industry, imparting a sweet, caramel-like aroma and taste to various products. Its unique olfactory profile adds depth and complexity to the sensory experience of consumables.
Used in Fine Chemicals Industry:
As a versatile intermediate, 3-METHYL-1H-PYRROLE-2-CARBALDEHYDE is used in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, such as research, specialty manufacturing, and high-value consumer products.

InChI:InChI=1/C6H7NO/c1-5-2-3-7-6(5)4-8/h2-4,7H,1H3

Upstream product

• 616-43-3 3-methylpyrrole 
• 68-12-2 N,N-dimethyl-formamide 
• 3284-46-6 benzyl-3-methylpyrrole-2-carboxylate 

Downstream Products

• 94781-48-3 4-bromo-3-methylpyrrole-2-carboxaldehyde 
• 1284257-69-7 4-bromo-3-methyl-2-formyl-N-tosylpyrrole 
• 1284257-67-5 6-(4-bromo-3-methyl-N-tosylpyrrol-2-yl)-1,1-dimethoxy-4,4-dimethyl-5-nitrohexan-2-one 
• 1284257-65-3 4-bromo-3-methyl-2-(2-nitroethyl)-N-tosylpyrrole 
• 90935-74-3 5-formyl-4-methyl-1H-pyrrole-2-carbaldehyde 
• 154367-56-3 7-Methylpyrrolizin-3-one 

Relevant articles and documents

PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS

The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, R6, X1, X2, m, and n are described herein.

Synthesis of 2,2′-bipyrrole-5-carboxaldehydes and their application in the synthesis of B-ring functionalized prodiginines and tambjamines

Facile, versatile, and cost-effective synthetic routes for the preparation of a range of new 3-alkyl-, 4-alkyl-, 3,4-dialkyl-, and 3-halo-4-alkyl-2, 2′-bipyrrole-5-carboxaldehydes have been developed. These 2,2′-bipyrrole-5-carboxaldehydes offer interesting potential as building blocks for making bioactive natural and unnatural products, as demonstrated by the synthesis of B-ring functionalized prodiginines (PGs) and tambjamines.

Pyrrolotriazine inhibitors of kinases

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Novel Substituent Orientation in Reimer-Tiemann Reactions of Pyrrole-2-carboxylates

Reimer-Tiemann formylation reactions (base/CHCl3) on 5-substituted pyrrole-2-carboxylates (1, 6, 8, 9, 11, and 13) afford 2-formylpyrroles (5, 7, 10, 12, and 14) in which the formyl group is situated in the position originally occupied by the carboxylate

Metabolites of the Marine Sponge Laxosuberites sp.

The marine sponge Laxosuberites sp. contained a mixture of four 5-alkylpyrrole-2-carboxaldehydes 1, (6'Z)-5-(12'-cyano-6'-dodecenyl)pyrrole-2-carboxaldehyde (2), and (6'Z)-5-(23'-cyano-23'-hydroxy-6'-tricosenyl)pyrrole-2-carboxaldehyde (3).The structures of the metabolites were determined by interpretation of spectral data and by chemical degradation.The cyanohydrin 3 is unusually stable to normal isolation and storage procedures.