- Determination of superoxide anion radical by modified CdTe quantum dots
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A novel fluorescence probe for determination of superoxide anion radical (O2[rad]?) was developed with CdTe quantum dots(QDs) modified by thiophene-2-formaldehyde shrinked L-cysteine Schiff base, which was characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), ultraviolet-visible (UV–vis) and fluorescent spectrum. The particle size of CdTe QDs was 3.1 nm as confirmed by X-ray powder diffraction pattern (XRD) and Transmission Electron Microscope (TEM) in presence of β-cysteamine (CA). The fluorescent results showed that the fluorescence intensity of CdTe QDs was decreased with modified Schiff base at 305 nm, but enhanced at 610 nm with O2[rad]? and showed an apparent linear dependence in the concentration scope of 2.0 × 10?5–1.0 × 10?4 mol L?1 (r = 0.9934) with a detection limit of 1.8 × 10?6 mol L?1, which exhibited high selectivity and stability towards O2[rad]?.
- Han, Jiaxing,Liu, Zheng,Guo, Yajin,Han, Guo-Cheng,Li, Wei,Chen, Siyang,Zhang, Shufen
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- THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF
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The present invention relates to thiazole compounds of formula I , the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses
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Paragraph 0057
(2014/04/03)
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- THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF
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The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses
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Paragraph 0106
(2014/06/11)
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- A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors
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Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.
- Larsen, Scott D.,Stachew, Carl F.,Clare, Paula M.,Cubbage, Jerry W.,Leach, Karen L.
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p. 3491 - 3495
(2007/10/03)
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