24044-07-3

Basic information

• Product Name: 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: IFLAB-BB F2124-0616;CHEMBRDG-BB 4003398;2-THIEN-2-YL-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-(Thiophen-2-yl)thiazole-4-carboxylicacid;2-(2-thienyl)-1,3-thiazole-4-carboxylic acid(SALTDATA: FREE);4-Carboxy-2-(thien-2-yl)-1,3-thiazole, 2-(4-Carboxy-1,3-thiazol-2-yl)thiophene;2-thiophen-2-yl-1,3-thiazole-4-carboxylic acid
• CAS NO: 24044-07-3
• Molecular Formula: C₈H₅NO₂S₂
• Molecular Weight: 211.26
• Mol File: 24044-07-3.mol

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 441.5°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.515±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.43E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(24044-07-3)
• EPA Substance Registry System: 2-(2-THIENYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID(24044-07-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 24044-07-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-(2-Thienyl)-1,3-thiazole-4-carboxylic acid is utilized as a potential drug candidate for the treatment of various diseases due to its observed anti-inflammatory, antiviral, and antitumor properties. Its unique structure allows it to be a target for the development of new therapeutic agents.
Used in Anti-inflammatory Applications:
In the field of anti-inflammatory research, 2-(2-Thienyl)-1,3-thiazole-4-carboxylic acid is used as a compound with potential to mitigate inflammation, which is crucial for treating a range of conditions where inflammation is a key factor.
Used in Antiviral Applications:
2-(2-Thienyl)-1,3-thiazole-4-carboxylic acid is employed as an antiviral agent, leveraging its ability to combat viral infections, which is significant in the development of treatments for viral diseases.
Used in Antitumor Applications:
In oncology, 2-(2-Thienyl)-1,3-thiazole-4-carboxylic acid is used as an antitumor agent, showing promise in the fight against cancer due to its capacity to inhibit tumor growth and proliferation.
Used in Drug Development:
2-(2-Thienyl)-1,3-thiazole-4-carboxylic acid is used as a starting material or a building block in the synthesis of more complex molecules for drug development, taking advantage of its unique chemical properties to create novel therapeutic agents.

InChI:InChI=1/C8H5NO2S2/c10-8(11)5-4-13-7(9-5)6-2-1-3-12-6/h1-4H,(H,10,11)/p-1

Upstream product

• 24043-97-8 ethyl 2-(thiophen-2-yl)thiazole-4-carboxylate 
• 24044-05-1 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid 
• 20300-02-1 thiophene-2-carbothioamide 
• 14037-19-5 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid diethyl ester 
• 24044-03-9 2-thiophen-2-yl-thiazole-4,5-dicarboxylic acid 4-ethyl ester 
• 5813-89-8 2-thiophenylcarboxamide 
• 98-03-3 thiophene-2-carbaldehyde 
• 52-90-4 L-Cysteine 

Downstream Products

• 1147108-96-0 N-(2-carbamoylphenyl)-2-(2-thienyl)-1,3-thiazole-4-carboxamide 
• 306934-98-5 2-(2-thienyl)-4-thiazolecarboxylic acid chloride 
• 1029432-59-4 C₂₃H₂₆N₄O₃S₂ 

Relevant articles and documents

Determination of superoxide anion radical by modified CdTe quantum dots

A novel fluorescence probe for determination of superoxide anion radical (O2[rad]?) was developed with CdTe quantum dots(QDs) modified by thiophene-2-formaldehyde shrinked L-cysteine Schiff base, which was characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), ultraviolet-visible (UV–vis) and fluorescent spectrum. The particle size of CdTe QDs was 3.1 nm as confirmed by X-ray powder diffraction pattern (XRD) and Transmission Electron Microscope (TEM) in presence of β-cysteamine (CA). The fluorescent results showed that the fluorescence intensity of CdTe QDs was decreased with modified Schiff base at 305 nm, but enhanced at 610 nm with O2[rad]? and showed an apparent linear dependence in the concentration scope of 2.0 × 10?5–1.0 × 10?4 mol L?1 (r = 0.9934) with a detection limit of 1.8 × 10?6 mol L?1, which exhibited high selectivity and stability towards O2[rad]?.

THIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention relates to thiazole compounds of formula I , the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses

THIAZOLE COMPOUNDS, METHODS FOR PREPARATION AND USE THEREOF

The present invention relates to thiazole compounds of formula I, the method for preparation and use thereof. More specifically, the present invention relates to novel derivatives of natural product largazole, the method for preparing them and their uses

A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors

Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.