- O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids
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A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.
- Desai, Vidya G.,Naik, Sneha R.,Dhumaskar, Kashinath L.
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p. 1453 - 1460
(2016/09/23)
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- Synthesis of 3,5-diarylisoxazoles under solvent-free conditions using iodobenzene diacetate
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A simple and efficient method has been developed for conversion of chalcone oximes to 3,5-diaryl isoxazoles in excellent yields under solvent-free conditions. The synthesized compounds were characterized by infrared spectroscopy, 1H NMR, 13C NMR and HRMS.
- Chandra Sekhar, Kondapalli Venkata Gowri,Sasank, Thripuraribhatla Venkata Naga Varuna Tara,Nagesh, Hunsur Nagendra,Suresh, Narva,Naidu, Kalaga Mahalakshmi,Suresh, Amaroju
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p. 1045 - 1048
(2014/01/06)
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- Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues
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In order to get a clearer view on the active geometry of anti-invasive chalcones, we have prepared a number of isoxazoles and related substances as conformationally restrained mimics of 1,3-diarylpropenones, and also of (Z)-stilbenes. In vitro anti-invasi
- Roman, Bart I.,Ryck, Tine De,Dierickx, Laura,Vanhoecke, Barbara W.A.,Katritzky, Alan R.,Bracke, Marc,Stevens, Christian V.
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p. 4812 - 4819
(2012/09/08)
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- Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists
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A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In add
- Weidner-Wells, Michele A.,Henninger, Todd C.,Fraga-Spano, Stephanie A.,Boggs, Christine M.,Matheis, Michele,Ritchie, David M.,Argentieri, Dennis C.,Wachter, Michael P.,Hlasta, Dennis J.
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p. 4307 - 4311
(2007/10/03)
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