24097-20-9

Basic information

• Product Name: Isoxazole, 5-(4-chlorophenyl)-3-(4-Methoxyphenyl)-
• Synonyms: Isoxazole, 5-(4-chlorophenyl)-3-(4-Methoxyphenyl)-
• CAS NO: 24097-20-9
• Molecular Formula: C₁₆H₁₂ClNO₂
• Molecular Weight: 285.72498
• Mol File: 24097-20-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 185-186 °C
• Boiling Point: 453°C at 760 mmHg
• Flash Point: 227.8°C
• Appearance: /
• Density: 1.231g/cm³
• Vapor Pressure: 5.74E-08mmHg at 25°C
• Refractive Index: 1.581
• PKA: -2.59±0.25(Predicted)
• CAS DataBase Reference: Isoxazole, 5-(4-chlorophenyl)-3-(4-Methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 5-(4-chlorophenyl)-3-(4-Methoxyphenyl)-(24097-20-9)
• EPA Substance Registry System: Isoxazole, 5-(4-chlorophenyl)-3-(4-Methoxyphenyl)-(24097-20-9)

Safety Data

• Hazardous Substances Data: 24097-20-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H12ClNO2/c1-19-14-8-4-11(5-9-14)15-10-16(20-18-15)12-2-6-13(17)7-3-12/h2-10H,1H3

Upstream product

• 6552-68-7 4'-methoxy-4-chlorochalcone 
• 107095-25-0 5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydroisoxazole 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 6552-68-7 4-chloro-4'-methoxy-chalcone 
• 104-88-1 4-chlorobenzaldehyde 
• 873-73-4 4-n-chlorophenylacetylene 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 2475-92-5 4-methoxyacetophenone oxime 
• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 p-methoxyl benzaldoxime 

Downstream Products

• 43016-11-1 4-[5-(4-chloro-phenyl)-isoxazol-3-yl]-phenol 

Relevant articles and documents

O-iodoxy benzoic acid–mediated synthesis of 3,5-diarylisoxazoles and isoxazole-3-carboxylic acids

A new, convenient, ecofriendly synthesis of 3,5-diarylisoxazoles is reported from a,b-unsaturated ketoximes. Similarly, a novel synthesis of isoxazole carboxylic acids is also reported. Both the methods use efficient, environmentally friendly, and nontoxic iodoxybenzoic acid (IBX) as an oxidative cyclizing reagent. Easy procedure, environmentally benign reaction conditions, and nontoxicity are advantages to the methodology.

Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues

In order to get a clearer view on the active geometry of anti-invasive chalcones, we have prepared a number of isoxazoles and related substances as conformationally restrained mimics of 1,3-diarylpropenones, and also of (Z)-stilbenes. In vitro anti-invasi