- Studies on isoxazole formation from alkyl carboxylic esters
-
Alkylisoxazoles 1a - 12a were prepared in moderate to high yields (58-83%) by condensation of 1.5 equivalents of the appropriate ketone oximes with an alkyl ester, followed by a mineral acid induced cyclization-dehydration reaction.
- He,Lin
-
-
Read Online
- Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position
-
A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.
- Shigenobu, Masashi,Takenaka, Kazuhiro,Sasai, Hiroaki
-
supporting information
p. 9572 - 9576
(2015/08/11)
-
- Trisubstituted isoxazoles from 3,4-disubstituted-(2H)-isoxazol-5-ones
-
A new trisubstituted isoxazole synthesis, starting from 3,4- disubstituted-(2H)-isoxazol-5-ones, is reported.
- Beccalli, Egle M.,Gelmi, Maria Luisa,Marchesini, Alessandro
-
p. 14401 - 14406
(2007/10/03)
-
- Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes
-
The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline
- Alberola, Angel,Banez, J. Manuel,Calvo, Luis,Rodriguez, M. Teresa Rodriguez,Sanudo, M. Carmen
-
p. 467 - 471
(2007/10/02)
-
- Synthesis of Isomeric Series of Aryltetrahydrobenzisoxazoles and Arylcyclopentisoxazoles
-
Four series of potential PAF-antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five- or six-carbon ring were prepared.The synthesis of the compounds 3-aryl-4,5,6,7-tetrahydrobenzisoxazoles 1, 3-arylcyclopentisoxazole 2,
- Fos, Empar,Borras, Liset,Gasull, Maria,Mauleon, David,Carganico Germano
-
p. 203 - 208
(2007/10/02)
-
- SYNTHESIS OF ISOXAZOLE DERIVATIVES IN REACTION OF 2-HYDROXYPHENYLCARBONYL COMPOUNDS OR 1,3-DIKETONES WITH HYDROXYLAMINE-O-SULFONIC ACID
-
2-Hydroxybenzaldehyde 1a and 2-hydroxyacetophenone 1b react with hydroxylamine-O-sulfonic acid (HSA) yielding the corresponding oxime hydrogensulfates 2a and 2b, separated as potassium salts.These salts undergo conversion with good yields to benzisoxazole 3a and 2-methylbenzoxazole 3b, respectively.In similar reaction of 1,3-diketones, both cyclic and acyclic 1c-k with HSA, isoxazole derivatives 3c-k were obtained.
- Suwinski, J.,Walczak, K.
-
p. 777 - 785
(2007/10/02)
-
- Halogenation of Vinyl Ketoximes. Synthesis of Isoxazoles and Preparation and Silver Ion-Promoted Reactions of 4-Halo-2-isoxazolines
-
Reaction of several α,β-unsaturated ketoximes with N-bromosuccinimide (NBS) gave isoxazoles, but yields were lower and the reaction less general than a similar transformation using iodine under basic conditions.With β,β-disubstituted oximes, 4-halo-5,5-disubstituted-2-isoxazolines were obtained using NBS, iodine, or N-chlorosuccinimide.Treatment of the 4-bromoisoxazolines with silver acetate or silver nitrate caused either elimination with rearrangement to give isoxazoles or substitution at C-4, depending upon the nature of the substituents at C-5.
- Hansen, John F.,Kim, Yong In,McCrotty, Stephen E.,Strong, Scott A.,Zimmer, Douglas E.
-
p. 475 - 479
(2007/10/02)
-