24097-27-6Relevant academic research and scientific papers
Studies on isoxazole formation from alkyl carboxylic esters
He,Lin
, p. 989 - 992 (1994)
Alkylisoxazoles 1a - 12a were prepared in moderate to high yields (58-83%) by condensation of 1.5 equivalents of the appropriate ketone oximes with an alkyl ester, followed by a mineral acid induced cyclization-dehydration reaction.
Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position
Shigenobu, Masashi,Takenaka, Kazuhiro,Sasai, Hiroaki
supporting information, p. 9572 - 9576 (2015/08/11)
A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The C-H bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.
Trisubstituted isoxazoles from 3,4-disubstituted-(2H)-isoxazol-5-ones
Beccalli, Egle M.,Gelmi, Maria Luisa,Marchesini, Alessandro
, p. 14401 - 14406 (2007/10/03)
A new trisubstituted isoxazole synthesis, starting from 3,4- disubstituted-(2H)-isoxazol-5-ones, is reported.
Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes
Alberola, Angel,Banez, J. Manuel,Calvo, Luis,Rodriguez, M. Teresa Rodriguez,Sanudo, M. Carmen
, p. 467 - 471 (2007/10/02)
The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline
Synthesis of Isomeric Series of Aryltetrahydrobenzisoxazoles and Arylcyclopentisoxazoles
Fos, Empar,Borras, Liset,Gasull, Maria,Mauleon, David,Carganico Germano
, p. 203 - 208 (2007/10/02)
Four series of potential PAF-antagonists in which the isoxazole nucleus is condensed with a polyhydrogenated five- or six-carbon ring were prepared.The synthesis of the compounds 3-aryl-4,5,6,7-tetrahydrobenzisoxazoles 1, 3-arylcyclopentisoxazole 2,
SYNTHESIS OF ISOXAZOLE DERIVATIVES IN REACTION OF 2-HYDROXYPHENYLCARBONYL COMPOUNDS OR 1,3-DIKETONES WITH HYDROXYLAMINE-O-SULFONIC ACID
Suwinski, J.,Walczak, K.
, p. 777 - 785 (2007/10/02)
2-Hydroxybenzaldehyde 1a and 2-hydroxyacetophenone 1b react with hydroxylamine-O-sulfonic acid (HSA) yielding the corresponding oxime hydrogensulfates 2a and 2b, separated as potassium salts.These salts undergo conversion with good yields to benzisoxazole 3a and 2-methylbenzoxazole 3b, respectively.In similar reaction of 1,3-diketones, both cyclic and acyclic 1c-k with HSA, isoxazole derivatives 3c-k were obtained.
Halogenation of Vinyl Ketoximes. Synthesis of Isoxazoles and Preparation and Silver Ion-Promoted Reactions of 4-Halo-2-isoxazolines
Hansen, John F.,Kim, Yong In,McCrotty, Stephen E.,Strong, Scott A.,Zimmer, Douglas E.
, p. 475 - 479 (2007/10/02)
Reaction of several α,β-unsaturated ketoximes with N-bromosuccinimide (NBS) gave isoxazoles, but yields were lower and the reaction less general than a similar transformation using iodine under basic conditions.With β,β-disubstituted oximes, 4-halo-5,5-disubstituted-2-isoxazolines were obtained using NBS, iodine, or N-chlorosuccinimide.Treatment of the 4-bromoisoxazolines with silver acetate or silver nitrate caused either elimination with rearrangement to give isoxazoles or substitution at C-4, depending upon the nature of the substituents at C-5.
