2410-19-7 Usage
Uses
Used in Pharmaceutical Industry:
6-methylergoline-8beta-carboxamide is used as an active pharmaceutical ingredient for the development of drugs targeting specific medical conditions. Its unique structure allows for the modulation of various biological pathways, making it a promising candidate for the treatment of different diseases.
Used in Research and Development:
6-methylergoline-8beta-carboxamide is utilized as a research compound in the field of medicinal chemistry. It serves as a valuable tool for understanding the mechanisms of action of various drugs and for the development of novel therapeutic agents.
Used in Drug Metabolism Studies:
As a metabolite of Dihydroergotamine, 6-methylergoline-8beta-carboxamide is used in drug metabolism studies to investigate the pharmacokinetics and pharmacodynamics of the parent compound. This helps in understanding the metabolic pathways and potential side effects of the drug.
Used in α-Androgenic Blocker Development:
6-methylergoline-8beta-carboxamide is used as a selective venoconstrictor in the development of α-androgenic blockers. Its venoconstrictor properties contribute to the selective therapeutic action of Dihydroergotamine, making it a valuable compound for the development of drugs targeting specific medical conditions.
Used in Drug Delivery Systems:
Similar to gallotannin, 6-methylergoline-8beta-carboxamide can be incorporated into drug delivery systems to enhance its bioavailability and therapeutic outcomes. Various organic and metallic nanoparticles can be employed as carriers for the delivery of this compound, aiming to improve its efficacy and safety profile in treating specific medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 2410-19-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,1 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2410-19:
(6*2)+(5*4)+(4*1)+(3*0)+(2*1)+(1*9)=47
47 % 10 = 7
So 2410-19-7 is a valid CAS Registry Number.
2410-19-7Relevant articles and documents
(8β)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity
Misner,Garbrecht,Marzoni,Whitten,Cohen
, p. 652 - 656 (2007/10/02)
A series of (8β)-6-methylergoline amide derivatives was synthesized with various alkyl substituents in the N1-position in order to evaluate their effectiveness in blocking vascular 5HT2 receptors. The influence of both the N1 substituent and amide derivative proved to be of great importance on binding affinities to vascular 5HT2 receptors. Within each series of amides, however, maximum affinity was achieved with an N1-isopropyl substituent (14, 18, 26, 38, and 41; all with 2.7-5.0 times greater affinity than their N1-H analogues), with the exception of two cases (22 and 37) in the cyclohexylamide derivatives wherein N1-methyl equalled the isopropyl in potency. Other than these exceptions, affinities followed the pattern of H Me Et iPr, with potencies falling off with larger alkyl substituents.
THERMAL DECOMPOSITION OF DIHYDROERGOCRISTINE METHANESULPHONATE
Rucman, Rudolf,Stanovnik, Branko
, p. 2229 - 2232 (2007/10/02)
By thermal decomposition of dihydroergocristine methanesulfonate (1a*CH3SO3H) are formed dihydrolysergyldehydrovaline methyl ester (2), dihydrolysergyldehydrovaline azlactone (3c), dihydrolysergic acid (3a), dihydrolysergamide (3b), S-phenylalanyl-S-proline lactam (4a) and S-phenylalanyl-R-proline lactam (4b).
