6-methylergoline-8beta-carboxamide

Base Information

• Chemical Name: 6-methylergoline-8beta-carboxamide
• CAS No.: 2410-19-7
• Molecular Formula: C16H19 N3 O
• Molecular Weight: 269.346
• Mol file: 2410-19-7.mol

Synonyms:Ergoline-8b-carboxamide, 6-methyl- (8CI);Lysergamide, dihydro- (6CI,7CI); Indolo[4,3-fg]quinoline, ergoline-8-carboxamidederiv.; 9,10-Dihydro-D-lysergic acid amide; 9,10-Dihydroergin;Dihydrolysergamide; Dihydrolysergic acid amide

Chemical Property of 6-methylergoline-8beta-carboxamide

Chemical Property:

• Melting Point: 280-281 °C
• Boiling Point: 550.4±50.0 °C(Predicted)
• PKA: 16.33±0.20(Predicted)
• Flash Point: 280.3oC
• PSA: 63.11000
• Density: 1.268±0.06 g/cm3(Predicted)
• LogP: 2.70080

Purity/Quality:

98%Min ^*data from raw suppliers

Dihydrolysergamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dihydrolysergamide is metabolite of Dihydroergotamine (D449080), α-Androgenic blocker with selective venoconstrictor properties. Dihydrolysergamide was also shown to exhibit considerable venoconstrictor activity which may contribute to the selective therapeutic action of Dihydroergotamine.

Technology Process of 6-methylergoline-8beta-carboxamide

There total 5 articles about 6-methylergoline-8beta-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 1.3%

9,10-dihydroergocristine methanesulphonate → dihydrolysergyldehydrovaline azalactam (88299-13-2) + dihydrolysergyldehydrovaline methyl ester (88299-12-1) + (3S,8aS)-3-benzyloctahydropyrrolo[1,2-a]pyrazine-1,4-dione (5654-85-3,14705-60-3,26488-24-4,32021-26-4,43041-16-3,43041-30-1,3705-26-8) + 6-methyl-ergoline-8-carboxylic acid amide (2410-19-7)

Guidance literature:

at 190 ℃; for 0.5h; Further byproducts given;

Reference yield:

→ 6-methyl-ergoline-8-carboxylic acid amide (2410-19-7)

Guidance literature:

at 200 - 220 ℃; under 0.001 Torr;

DOI:10.1093/imanum/20.4.499

Reference yield:

1,1'-carbonyldiimidazole (530-62-1) + 9,10-dihydrolysergic acid (5878-43-3) → 6-methyl-ergoline-8-carboxylic acid amide (2410-19-7)

Guidance literature:

In dichloromethane; for 1h;

DOI:10.1021/jm00164a029

upstream raw materials:

1,1'-carbonyldiimidazole

9,10-dihydrolysergic acid

Downstream raw materials:

FCE 22716