- Copper-Catalyzed Oxidative Cyclization of 2-Aminobenzamide Derivatives: Efficient Syntheses of Quinazolinones and Indazolones
-
A simple copper-catalyzed assembly to formulate quinazolinone and indazolone derivatives in a single protocol manner is reported. These transformations are based on the fact that DMF can serve as a reaction solvent and one carbon synthon for the construct
- Govindan, Karthick,Duraisamy, Tamilselvan,Jayaram, Alageswaran,Senadi, Gopal Chandru,Lin, Wei-Yu
-
supporting information
p. 1115 - 1124
(2021/12/02)
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- New and efficient synthesis of 3-arylquinazolin-4(1H)-ones and biologically important N-fused tetracycles based on N-(2-carboxyphenyl)oxalamide
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A novel clean, one-pot syntheses of 3-arylquinazolin-4(3H)-ones and quinoxalino[2,1-b]quinazoline-6,12(5H)-diones via PPA-mediated coupling of N-(2-carboxyphenyl)oxalamides with arylamines and 1,2-benzenediamines have been developed. Under mild reaction conditions with use of Na2S2O4 the benzimidazo[2,1-b]quinazolin-12-ones were achieved in good yield from 3-(2-nitrophenyl)quinazolin-4-ones.
- Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Gubaidullin, Aidar T.,Voronina, Julia K.,Kushatov, Temur A.,Korshin, Dmitry E.,Samigullina, Aida I.,Tanysheva, Ekaterina G.,Kh. Rizvanov, Il'dar,Latypov, Shamil K.
-
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- Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides
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A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides has been achieved. This transition-metal and oxidant-free strategy has been applied to the construction of various N-heterocyles such as quinazolinone, benzimidazole and benzothiazole derivatives by the use of distinct amino-based binucleophiles. The notable feature of this protocol includes its mild reaction condition, broad functional group tolerance and excellent yield. This journal is
- Chen, Fen-Er,Dong, Lin,Li, Hongyan,Liu, Jinxin,Luo, Liangliang,Xiao, You-Cai,Zhou, Yuan
-
p. 29257 - 29262
(2020/10/02)
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- Facile access to: N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones
-
N-Formamide synthesis using N-formyl imide with primary and secondary amines with catalytic amounts of p-toluenesulfonic acid monohydrate (TsOH·H2O) is described. This reaction is performed in water without the use of surfactants. Moreover, N-formyl imide is efficiently synthesized using acylamidines with TsOH·H2O in water. In addition, N-formyl imide was successfully used as a carbonyl source in the synthesis of benzimidazole and quinazolinone derivatives. Notable features of N-formylation of amines by using N-formyl imide include operational simplicity, oxidant- A nd metal-free conditions, structurally diverse products, and easy applicability to gram-scale operation.
- Huang, Hsin-Yi,Liang, Chien-Fu,Lin, Xiu-Yi,Yen, Shih-Yao
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supporting information
p. 5726 - 5733
(2020/08/21)
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- Metal-free C-H methylation and acetylation of heteroarenes with PEG-400
-
The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.
- Kudale, Vishal Suresh,Wang, Jeh-Jeng
-
supporting information
p. 3506 - 3511
(2020/06/25)
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- New Strategy for the Synthesis of Heterocycles via Copper-Catalyzed Oxidative Decarboxylative Amination of Glyoxylic Acid
-
A copper-catalyzed oxidative decarboxylative amination of glyoxylic acid with substrates having two nitrogen-nucleophilic sites was first demonstrated. Using this novel approach, 1,3,5-triazines, quinazolinones and quinazolines were obtained in up to 93 % yields. Notably, glyoxylic acid was employed as the C1 synthon for heterocycles. This strategy enriches the application of glyoxylic acid for the synthesis of valuable heterocycles.
- Niu, Bin,Li, Shaoqing,Cui, Chang,Yan, Yizhe,Tang, Lin,Wang, Jianyong
-
supporting information
p. 7800 - 7803
(2019/11/28)
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- Transition metal-free C-F/C-Cl/C-C cleavage of ClCF2COONa for the synthesis of heterocycles
-
A transition metal-free and external oxidant-free annulation of substrates having two nitrogen-nucleophilic sites with ClCF2COONa was demonstrated, affording a series of 1,3,5-triazines and quinazolinones in up to 96% yields. Notably, ClCF
- Yan, Yizhe,Cui, Chang,Wang, Jianyong,Li, Shaoqing,Tang, Lin,Liu, Yanqi
-
supporting information
p. 8071 - 8074
(2019/09/19)
-
- Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions
-
Alcohols and ethers were identified as sustainable methine sources for synthesizing quinazolinone and benzimidazole derivatives using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone (2e′), 2f′ (a common precursor of rutaecarpine and (±) evodiamine), and dimedazole (6d). Notable features of this method include its low toxicity, use of commercial feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.
- Senadi, Gopal Chandru,Kudale, Vishal Suresh,Wang, Jeh-Jeng
-
supporting information
p. 979 - 985
(2019/03/12)
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- Furan-2-carbaldehydes as C1 building blocks for the synthesis of quinazolin-4(3: H)-ones via ligand-free photocatalytic C-C bond cleavage
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Furan-2-carbaldehydes, as biomass-derived chemicals, are used as efficient green C1 building blocks to synthesize bioactive quinazolin-4(3H)-ones by ligand-free photocatalytic C-C bond cleavage. Notably, protection of hydroxyl, carboxyl, amide, or secondary amino groups is not required. Mechanistic studies suggest that conjugated N,O-tridentate copper complexes act as novel photoinitiators under visible light.
- Yu, Wenjia,Zhang, Xianwei,Qin, Bingjie,Wang, Qiyang,Ren, Xuhong,He, Xinhua
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p. 2449 - 2454
(2018/06/11)
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- Synthesis of Quinazolinones, Imidazo[1,2-c]quinazolines and Imidazo[4,5-c]quinolines through Tandem Reductive Amination of Aryl Halides and Oxidative Amination of C(sp3)–H Bonds
-
A tandem multicomponent approach has been described for the synthesis of quinazolinones, imidazo[1,2-c]quinazolines and imidazo[4,5-c]quinolines. The reaction involves a copper-catalyzed reductive amination through azidation followed by reduction and oxidative amination of C(sp3)–H bonds of N,N-dimethylacetamide in the presence of TBHP (tert-butylhydroperoxide) as oxidant. The method uses the easily available sodium azide as a nitrogen source and DMA (N,N-dimethylacetamide) as a one-carbon source for the synthesis of these N-fused heterocycles in good to excellent yields. The reaction can also be used for gram-scale synthesis.
- Nandwana, Nitesh Kumar,Dhiman, Shiv,Saini, Hitesh Kumar,Kumar, Indresh,Kumar, Anil
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p. 514 - 522
(2017/02/05)
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- Pd/C as an efficient heterogeneous catalyst for carbonylative four-component synthesis of 4(3H)-quinazolinones
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Quinazolinones are of interest in the fields of pharmaceuticals and medicinal chemistry. The application of palladium on activated charcoal (Pd/C) as a heterogeneous catalyst was investigated for the carbonylation of 2-iodoanilines with trimethyl orthofor
- Natte, Kishore,Neumann, Helfried,Wu, Xiao-Feng
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p. 4474 - 4480
(2015/09/01)
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- Copper-catalyzed radical methylation/C-H amination/oxidation cascade for the synthesis of quinazolinones
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A copper-catalyzed radical methylation/sp3 C-H amination/oxidation reaction for the facile synthesis of quinazolinone was developed. In this cascade reaction, dicumyl peroxide acts not only as a useful oxidant but also as an efficient methyl source. Notably, a methyl radical, generated from peroxide, was confirmed by electron paramagnetic resonance for the first time.
- Bao, Yajie,Yan, Yizhe,Xu, Kun,Su, Jihu,Zha, Zhenggen,Wang, Zhiyong
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p. 4736 - 4742
(2015/05/13)
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- Convenient synthesis of 2,3-disubstituted quinazolin-4(3H)-ones and 2-styryl-3-substituted quinazolin-4(3H)-ones: Applications towards the synthesis of drugs
-
Simple, convenient, and green synthetic protocols have been developed for the one pot synthesis of 2,3-disubstituted quinazolin-4(3H)-ones and 2-styryl-3-substituted quinazolin-4(3H)-ones under catalyst and solvent free conditions. The multicomponent reaction (3-MCR) involving isatoic anhydride, an amine, and orthoester afforded the 2,3-disubstituted quinazolin-4(3H)-ones in excellent yields under classical heating at 120 °C for 5 h or under microwave irradiation at 140°C for 20-30 min. The use of ammonium acetate instead of the amine provides the 2-substituted quinazolin-4(3H)-ones. The reactions are compatible with various substituted isatoic anhydrides, aryl/heteroaryl/alkyl/cycloalkyl amines, and orthoesters. The strategies are extended to the one pot tandem condensation involving isatoic anhydride, an amine, orthoester, and aldehyde to afford highly functionalized (E)-3-aryl/heteroaryl-2-styrylquinazolin/(2-(heteroaryl)vinyl)quinazolin-4(3H)-ones. The applications of the methodologies are demonstrated through the synthesis of various drugs which act on the central nervous system such as methaqualone, mebroqualone, mecloqualone, piriquialone, and diproqualone.
- Kumar, Dinesh,Jadhavar, Pradeep S.,Nautiyal, Manesh,Sharma, Himanshu,Meena, Prahlad K.,Adane, Legesse,Pancholia, Sahaj,Chakraborti, Asit K.
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p. 30819 - 30825
(2015/04/22)
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- Metal-free oxidative synthesis of quinazolinones via dual amination of sp3 C-H bonds
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A novel metal-free synthesis of quinazolinones via dual amination of sp3 C-H bonds was developed. The sp3 carbon in methylarenes or adjacent to a heteroatom in DMSO, DMF or DMA was used as the one carbon synthon. This journal is the Partner Organisations 2014.
- Zhao, Dan,Wang, Teng,Li, Jian-Xin
-
supporting information
p. 6471 - 6474
(2014/06/09)
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- Highly efficient four-component synthesis of 4(3H)-quinazolinones: Palladium-catalyzed carbonylative coupling reactions
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Given the importance of quinazolinones and carbonylative transformations, a palladium-catalyzed fourcomponent carbonylative coupling system for the synthesis of diverse 4(3H)-quinazolinone in a concise and convergent fashion has been developed. Starting from 2-bromoanilines (1 mmol), trimethyl orthoformate (2 mmol), and amines (1.1 mmol), under 10 bar of CO, the desired products were isolated in good yields in the presence of Pd(OAc)2 (2 mol%), BuPAd2 (6 mol%) in 1,4-dioxane (2 mL) at 1008C, using N,Ndiisopropylethylamine (2 mmol) as the base. Notably, the process tolerates the presence of various reactive functional groups and is very selective for quinazolinones, and was used in the synthesis of the precursor to the bioactive dihydrorutaempine.
- He, Lin,Li, Haoquan,Neumann, Helfried,Beller, Matthias,Wu, Xiao-Feng
-
supporting information
p. 1420 - 1424
(2014/03/21)
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- Glyoxylic acid in the reaction of isatoic anhydride with amines: A rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones leading to rutaecarpine and evodiamine
-
A dual reactant/catalyst role of glyoxylic acid in the reaction of isatoic anhydride with various amines afforded a novel, robust and rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones. This metal catalyst-free reaction proceeds via an unusual and unexpected cleavage of C-C bond. A shorter and common route to two alkaloids, that is, rutaecarpine and evodiamine is also accomplished.
- Rao, K. Raghavendra,Raghunadh, Akula,Mekala, Ramamohan,Meruva, Suresh Babu,Pratap,Krishna,Kalita, Dipak,Laxminarayana, Eppakayala,Prasad, Bagineni,Pal, Manojit
-
supporting information
p. 6004 - 6006
(2014/12/12)
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- An efficient, greener, and solvent-free one-pot multicomponent synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones
-
Herein, we report an efficient, greener, and solvent-free novel method for the synthesis of 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H) ones in a one-pot sequence using methyl anthranilate or 2-aminothiophene-3- carboxylate with N,N′-dimethyl formamide dimethyl acetal and various anilines. The driving force for this reaction is the removal of N,N′-dimethylamine by various anilines resulting in 3-substituted quinazolin-4(3H)ones and thienopyrimidin-4(3H)ones.
- Jalani, Hitesh B.,Pandya, Amit N.,Pandya, Dhaivat H.,Sharma, Jayesh A.,Sudarsanam,Vasu, Kamala K.
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p. 4062 - 4064
(2012/08/28)
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- Synthesis of 3-substituted and 2,3-disubstituted quinazolinones via Cu-catalyzed aryl amidation
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CuI/4-hydroxy-l-proline catalyzed coupling of N-substituted o-bromobenzamides with formamide takes place at 80 °C, affording 3-substituted quinazolinones directly. Under these conditions other amides that were tested only provided simple coupling products, which can be converted into 2,3-disubstituted quinazolinones via HMDS/ZnCl2 mediated condensative cyclization.
- Xu, Lanting,Jiang, Yongwen,Ma, Dawei
-
supporting information; experimental part
p. 1150 - 1153
(2012/03/27)
-
- Aluminium nitrate-catalyzed one-pot synthesis of 4(3h)-quinazolinones by a three-component coupling of anthranilic acid, amines, and ortho esters
-
The one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid, amines, and ortho esters in the presence of aluminium nitrate has been carried out. The reaction occurred in a few minutes at room temperature under solvent-free con
- Wang, Min,Song, Zhiguo,Zhang, Tingting
-
experimental part
p. 385 - 391
(2011/04/15)
-
- Dabco as a novel and efficient catalyst for the synthesis of 4(3H)-Quinazolinone derivatives
-
4(3H)-Quinazolinones were synthesized in high to excellent yields through the one-pot condensation of anthranilic acid, trimethyl orthoformate and primary amines in the presence of DABCO under solvent free conditions.
- Heravi, Majid M.,Javanmardi, Najme,Oskooie, Hossein A.,Baghernejad, Bita
-
scheme or table
p. 305 - 308
(2012/04/17)
-
- Synthesis of 4-(3H)-quinazolinones by microwave assisted tandem reaction and evaluation of their antibacterial and antifungal activities
-
A one-pot synthesis of quinazolinone derivatives from the reaction of anthranilic acid and primary aromatic amines with Vilsmeier reagent (DMF/POCl3) has been carried out. The reaction occurred in a few minutes under microwave irradiation provi
- Priya, M. Gnana Ruba,Zulykama,Girija,Murugesh,Perumal
-
experimental part
p. 98 - 102
(2011/04/22)
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- Strontium chloride-catalyzed one-pot synthesis of 4(3H)-quinazolinones under solvent-free conditions
-
Strontium chloride was used as an efficient and recyclable catalyst in one-pot condensation of anthranilic acid, ortho esters and amines leading to the formation of 4(3. H)-quinazolinone derivatives in good yields at room temperature under solvent-free co
- Wang, Min,Song, Zhi Guo,Zhang, Ting Ting
-
experimental part
p. 1167 - 1170
(2011/10/12)
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- Synthesis of 3-Aryl-4(3H)-quinazolinones from anthranilic acid, ortho esters, and anilines using Ce(CH3SO3)3· 2H2O as catalyst
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3-Aryl-4(3H)-quinazolinones were synthesized efficiently by the three component one-pot cyclocondensation of anthranilic acid, ortho esters, and anilines in the presence of Ce(CH3SO3)3·2H 2O at room temperature under solve
- Wang, Min,Song, Zhi-Guo,Zhang, Ting-Ting
-
experimental part
p. 993 - 996
(2011/10/02)
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- SnCl2·2H2O-catalyzed one-pot synthesis of 4(3H)-quinazolinones from anthranilic acid, ortho esters, and amines under solvent free conditions
-
(Chemical Equation Presented) A simple, efficient, and green procedure for the one-pot synthesis of 4(3H)-quinazolinones by three components condensation of anthranilic acid, ortho esters, and amines in the presence of SnCl 2·2H2O ha
- Wang, Min,Song, Zhiguo,Zhang, Tingting
-
experimental part
p. 468 - 471
(2010/06/19)
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- Ultrasound promoted and ionic liquid catalyzed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones
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4(3H)-Quinazolinones were synthesized in high yields by one-pot three-component condensation of anthranilic acid, carboxylic acid and aniline in the presence of ionic liquid such as 1-n-butyl-3-methylimidazolium tetrafluoroborate (BMImBF4) as c
- Pawar, Omprakash B.,Chavan, Fulchand R.,Sakate, Sachin S.,Shinde, Narayan D.
-
experimental part
p. 69 - 71
(2010/09/05)
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- Silica-supported boron trifluoride (BF3-SiO2): An efficient, environment friendly and recyclable catalyst for the one-pot synthesis of 4(3H)-quinazolinones
-
A simple and efficient synthesis of 4(3H)-quinazolinones has been accomplished by the one-pot condensation of anthranilic acid, triethylorthoformate and primary amines under solvent-free conditions in the presence of BF3-SiO2.
- Wu, Liqiang,Ma, Weiwei,Yang, Limin,Yan, Fulin
-
experimental part
p. 6053 - 6058
(2010/12/19)
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- Iodine: Selectively promote the synthesis of mono substituted quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones in one-pot
-
(Chemical Equation Presented) A general and versatile one-pot three-component procedure for the selective synthesis of mono substituted quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones were described. The selectivity could be controlled by the ratio of iodine concentration.
- Zeng, Li-Yan,Cai, Chun
-
experimental part
p. 1035 - 1039
(2010/10/21)
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- Eco-friendly, solvent-free novel one-pot, three-component synthesis of quinazolinones at ambient temperature catalyzed by silica gel-supported phosphomolybdic acid
-
(Chemical Presented) Silica gel supported Phosphomolybdic acid (PMA.SiO2) catalyzes efficiently the one-pot three-component coupling reaction of anthranilic acid, orthoesters, and amines at room temperature to afford 4(3H)-Quinazolinones in hig
- Sabitha, Gowravaram,Reddy, N. Mallikarjuna,Prasad, M. Nagendra,Raja,Yadav
-
experimental part
p. 589 - 593
(2010/09/05)
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- Silica-supported preyssler nanoparticles as new catalysts in the synthesis of 4(3H)-quinazolinones
-
A new and efficient method for the preparation of 4(3H)-quinazolinones from the condensation of anthranilic acid, orthoester and substituted anilines, in the presence of catalytic amounts of silica-supported Preyssler nanoparticles is reported. The cataly
- Heravi, Majid M.,Sadjadi, Samaheh,Sadjadi, Sodeh,Oskooie, Hossein A.,Shoar, R. Hekmat,Bamoharram, Fatemeh F.
-
experimental part
p. 1 - 4
(2010/09/04)
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- Copper(I) iodide catalyzed domino process to quinazolin-4(3H)-ones
-
An efficient synthesis of substituted quinazolin-4(3H)-ones by a one-pot ligand-free CuI-catalyzed coupling/condensative cyclization under mild conditions is described. Our study provides an alternative strategy for the preparation of biologically active quinazolin-4(3H)-ones. Georg Thieme Verlag Stuttgart.
- Zhou, Jing,Fu, Liangbing,Lv, Man,Liu, Jinsong,Pei, Duanqing,Ding, Ke
-
experimental part
p. 3974 - 3980
(2009/05/27)
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- A novel method for the synthesis of 4(3H)-quinazolinones
-
Different metal perchlorates were screened to catalyze the three-component reaction of anthranilic acid, triethyl orthoformate and amines to afford quinazolin-4(3H)-ones in solvent-free conditions. Ni(ClO4) 2 or Zn(ClO4)s
- Jing, Xiao-Bi,Li, Zhen,Pan, Xin,Shi, Yao-Cheng
-
experimental part
p. 1145 - 1149
(2009/12/08)
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- A microwave-assisted and heteropolyacids-catalysed cyclocondensation reaction for the synthesis of 4(3H)-quinazolinones
-
We have investigated a microwave-assisted synthesis of 4(3H)-quinazolinones by condensation of anthranilic acid, orthoesters (or formic acid) and substituted anilines, using Keggin-type heteropolyacids (H3PW 12O40·13H
- Ighilahriz, Karima,Boutemeur, Baya,Chami, Fariza,Rabia, Cherifa,Hamdi, Maamar,Hamdi, Safouane M.
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p. 779 - 789
(2008/09/18)
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- Zirconyl(IV) chloride catalyzed three component one-pot synthesis of quinazolin-4(3H)-ones
-
An efficient one-pot method for synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, triethyl orthoformate, and amines using ZrOCl2 is described. This method offers improvements for the synthesis of quinazolin-4(3H)-ones with r
- Sangshetti, Jaiprakash N.,Kokare, Nagnnath D.,Shinde, Devanand B.
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p. 1289 - 1291
(2008/03/28)
-
- Bi(TFA)3-[nbp]FeCl4: a new, efficient and reusable promoter system for the synthesis of 4(3H)-quinazolinone derivatives
-
4(3H)-Quinazolinones have been synthesized in high to excellent yields through the one-pot condensation of anthranilic acid, trimethyl orthoformate and primary amines in the presence of 5 mol % of Bi(TFA)3 immobilized on [nbp]FeCl4 a
- Khosropour, Ahmad R.,Mohammadpoor-Baltork, Iraj,Ghorbankhani, Hamid
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p. 3561 - 3564
(2007/10/03)
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- Convergent one-pot synthesis of 3-substituted quinazolin-4(3H)-ones under solvent-free conditions
-
A convenient method for the synthesis of 3-substituted quinazolin-4(3H)- ones using the convergent reactions of formic acid, a primary amine, and isatoic anhydride under solvent-free conditions and with brief microwave irradiation is described. Copyright Taylor & Francis Group, LLC.
- Rad-Moghadam, Kurosh,Mamghani, Manoochehr,Samavi, Laleh
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p. 2245 - 2252
(2007/10/03)
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- One-pot synthesis of mono- and disubstituted (3H)-quinazolin-4-ones in dry media under microwave irradiation
-
AlCl3/ZnCl2 mixture supported on silica gel is an efficient medium for one-pot synthesis of (3H)-quinazolin-4-ones in the absence of solvent under microwave irradiation or classical heating. The reaction of orthoesters with 2-aminobenzamides ends up with the formation of monosubstituted (3H)-quinazolin-4-ones. One-pot synthesis of disubstituted (3H)-quinazolin-4- ones is also achieved by the reaction of isatoic anhydride with primary amines and orthoesters.
- Dabiri, Minoo,Salehi, Peyman,Mohammadi, Ali A.,Baghbanzadeh, Mostafa
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p. 279 - 287
(2007/10/03)
-
- Synthesis of 3,4-dihydropyrimidine-2(1H)-thiones and quinazolin-4(3H)-ones over Yb(III)-resin catalyst under solvent-free conditions
-
Ytterbium(III) reagent supported on ion exchange resin is applied to the multicomponent condensation reactions under solvent-free conditions. One-pot synthesis of a library of 3,4-dihydropyrimidine-2(1H)-thiones and quinazolin-4(3H)-ones were described. The advantages of easy separation and recyclability of the catalysts were demonstrated.
- Jiang, Zhidong,Chen, Ruifang
-
p. 503 - 509
(2007/10/03)
-
- Facile synthesis of substituted quinazolin-4-(3H)-ones using low-valence titanium reagent
-
A short and facile synthesis of a series of 3-aryl quinazolin-4-(3H)-ones was accomplished in good yields via the intermolecular reductive coupling reaction of N-aryl-2-nitrobenzamide and triethyl orthoformate promoted by TiCl4/Zn.
- Shi, Daqing,Rong, Liangce,Wang, Juxian,Zhuang, Qiya,Wang, Xiangshan,Hu, Hongwen
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p. 1759 - 1765
(2007/10/03)
-
- A convenient synthesis of substituted quinazolin-4(3H)-ones under microwave and solvent-free conditions
-
A clean and facile synthesis of the title compounds is achieved from cyclocondensation of 2-aminobenzamides with orthoesters catalyzed by SiO 2/H2SO4 in dry and microwave conditions.
- Montazeri, Nasser,Rad-Moghadam, Kurosh
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p. 2533 - 2536
(2007/10/03)
-
- Synthesis of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones with the aid of a low-valent titanium reagent
-
A short and facile synthesis of a series of quinazolin-4(3H)-ones and 1,2-dihydroquinazolin-4(3H)-ones was accomplished in good yields via the novel reductive cyclization of o-nitrobenzamides and triethyl orthoformate, aldehydes or ketones promoted by TiCl4/Zn.
- Shi, Daqing,Rong, Liangce,Wang, Juxian,Zhuang, Qiya,Wang, Xiangshan,Hu, Hongwen
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p. 3199 - 3201
(2007/10/03)
-
- A novel reductive cross-coupling reaction of N-aryl-2-nitrobenzamide and triethyl orthoformate promoted by the TiCl4/Sm system: An access to 3-arylquinazolin-4 (3H)-ones
-
A short and facile synthesis of a series of 3-arylquinazolin-4(3H)-ones was accomplished in good yield via the intermolecular reductive coupling reaction of N-aryl-2-nitrobenzamide and triethyl orthoformate promoted by TiCl4/Sm.
- Shi, Daqing,Rong, Liangce,Wang, Juxian,Zhuang, Qiya,Hu, Hongwen
-
p. 366 - 367
(2007/10/03)
-
- Nickel boride mediated reductive desulfurization of 2-thioxo-4(3H)-quinazolinones: A new synthesis of quinazolin-4(3H)-ones and 2,3-dihydro-4(1H)-quinazolinones
-
A novel one-pot approach for the synthesis of aryl substituted quinazolin-4(3H)-ones and 2,3-dihydro-4(1H)-quinazolinones has been reported based on the reductive desulfurization of 3-aryl-2-thioxo-4(3H)-quinazolinones with nickel boride in dry methanol at ambient temperature.
- Khurana, Jitender M.,Kukreja, Gagan
-
p. 677 - 679
(2007/10/03)
-
- Yb(OTf)3-catalyzed one-pot synthesis of quinazolin-4(3H)-ones from anthranilic acid, amines and ortho esters (or formic acid) in solvent-free conditions
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An efficient synthesis of an array of quinazolin-4(3H)-ones from anthranilic acid, ortho esters (or formic acid) and amines using Yb(OTf)3 in one-pot under solvent-free conditions is described. Compared with the classical reaction conditions, this new synthetic method has the advantage of excellent yields (75-99%), shorter reaction time (few minutes) and reusability of the catalyst.
- Wang, Limin,Xia, Jianjun,Qin, Fang,Qian, Changtao,Sun, Jie
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p. 1241 - 1247
(2007/10/03)
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- One-pot Synthesis of Substituted Quinazolin-4(3H)-ones under Microwave Irradiation
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Synthesis of the title compounds by cyclocondensation of anthranilic acid, formic acid (or orthoesters) and an amine in one pot under microwave irradiation takes place in a few minutes.
- Rad-Moghadam, Kurosh,Khajavi, Mohammad S.
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p. 702 - 703
(2007/10/03)
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- Synthesis and in vitro study of platelet antiaggregant activity of 1,2,3,4-tetrahydroquinazoline derivatives
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Some original 3-substituted 1,2,3,4-tetrahydroquinazolines were synthesized. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by the main inducers (ADP, collagen, arachidonic acid), platelet serotonin release reaction and thromboxane A2 synthesis. All these molecules possess an inhibiting power which, compared to that of aspirin in the same conditions, is the same or greater when aggregation is induced by ADP.
- Gravier,Dupin,Casadebaig,Hou,Boisseau,Bernard
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p. 531 - 535
(2007/10/02)
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