cas 122-51-0, Triethyl orthoformate | Articles data

Articles about 122-51-0Total 21 be found

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Tamborski,Post
p. 1397
(1952)
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Mochel,Agre,Hanford
p. 2268
(1948)
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Erickson
p. 1569,1571
(1955)
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Alcoholysis of fluoroform
Fluoroform (CHF3) reacts with alkali metal alkoxides MOR (M = Na, K) in the corresponding alcohols ROH (R = Me, Et, i-Pr, t-Bu, and Allyl) at 80-120°C to give orthoformate esters HC(OR)3 in 55-90% yield. Particularly notable is the f
Miloserdov, Fedor M.,Grushin, Vladimir V.
p. 105 - 109
(2014)
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Synthesis method of crude carboxylic ester (by machine translation)
The method is characterized in that the carboxylic ester and the ether are prepared by reacting a carboxylic ester with an ether at a certain temperature under the catalysis of a catalyst at a certain pressure for a certain time. (by machine translation)
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Paragraph 0021; 0022

(2020/08/09)

Self-assembled orthoester cryptands: Orthoester scope, post-functionalization, kinetic locking and tunable degradation kinetics
Dynamic adaptability and biodegradability are key features of functional, 21st century host-guest systems. We have recently discovered a class of tripodal supramolecular hosts, in which two orthoesters act as constitutionally dynamic bridgeheads. Having previously demonstrated the adaptive nature of these hosts, we now report the synthesis and characterization-including eight solid state structures-of a diverse set of orthoester cages, which provides evidence for the broad scope of this new host class. With the same set of compounds, we demonstrated that the rates of orthoester exchange and hydrolysis can be tuned over a remarkably wide range, from rapid hydrolysis at pH 8 to nearly inert at pH 1, and that the Taft parameter of the orthoester substituent allows an adequate prediction of the reaction kinetics. Moreover, the synthesis of an alkyne-capped cryptand enabled the post-functionalization of orthoester cryptands by Sonogashira and CuAAC "click" reactions. The methylation of the resulting triazole furnished a cryptate that was kinetically inert towards orthoester exchange and hydrolysis at pH > 1, which is equivalent to the "turnoff" of constitutionally dynamic imines by means of reduction. These findings indicate that orthoester cages may be more broadly useful than anticipated, e.g. as drug delivery agents with precisely tunable biodegradability or, thanks to the kinetic locking strategy, as ion sensors.
L?w, Henrik,Mena-Osteritz, Elena,Von Delius, Max
p. 4785 - 4793
(2018/06/07)

Method for producing high purity orthoformate simple and convenient method of
The invention provides a simple and convenient method for producing high-purity ortho-formate by using acrylonitrile byproduct hydrocyanic acid. The method comprises the following steps: firstly producing amine salt from the acrylonitrile byproduct hydrocyanic acid, fatty alcohol and hydrogen chloride, subsequently performing alcoholysis reaction on the presence of corresponding fatty alcohol so as to obtain an ortho-formate reaction liquid, adding a proper amount of an alkali substance in the generated ortho-formate reaction liquid, decomposing nitrogenous impurity compounds such as byproduct 1,3,5-s-triazine at certain temperature, wherein the decomposed product is nitrogen and solid formate with low boiling point, performing aftertreatment on the reaction liquid so as to obtain the high-purity ortho-formate through normal distillation. Therefore, the purpose of producing the high-purity ortho-formate with high yield is achieved.
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Paragraph 0022-0028

(2017/12/04)

Green preparing orthoformate cleaning process
The invention provides a green process for preparing orthoformate. A hydrogen chloride alcohol solution is prepared from a byproduct hydrogen chloride tail gas of the chlorine-related synthesis industry and then is slowly added into a reaction system, so that loss caused by escape of hydrocyanic acid is reduced, the yield is increased, great equipment corrosion caused by the byproduct hydrochloric acid prepared by the companies is avoided, the economic additional value of the byproduct hydrogen chloride is greatly increased, three wastes are avoided, the byproduct only comprises ammonium chloride, resources are reasonably utilized, and the green process for preparing the orthoformate is an environment-friendly production process and has a good social benefit.
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Paragraph 0046; 0048; 0049

(2016/10/07)

Orthoester exchange: A tripodal tool for dynamic covalent and systems chemistry
Reversible covalent reactions have become an important tool in supramolecular chemistry and materials science. Here we introduce the acid-catalyzed exchange of O,O,O-orthoesters to the toolbox of dynamic covalent chemistry. We demonstrate that orthoesters readily exchange with a wide range of alcohols under mild conditions and we disclose the first report of an orthoester metathesis reaction. We also show that dynamic orthoester systems give rise to pronounced metal template effects, which can best be understood by agonistic relationships in a three-dimensional network analysis. Due to the tripodal architecture of orthoesters, the exchange process described herein could find unique applications in dynamic polymers, porous materials and host-guest architectures.
Brachvogel, Ren-Chris,Von Delius, Max
p. 1399 - 1403
(2015/02/05)

METHOD FOR THE PRODUCTION OF ORTHOESTERS
The invention relates to a method for the production of orthoesters, wherein a first orthoester and a first alcohol are guided into a rectification column such that in at least one area of the column the first orthoester and the first alcohol react with a second orthoester and a second alcohol, and the second orthoester and the second alcohol are removed from the reaction area.
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Page/Page column 7-8

(2008/06/13)

4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
The present invention provides a compound of formula I Wherein R1is C1-7alkyl, optionally substituted by hydroxy or NR4R5; R2is C1-7alkyl substituted by hydroxy or NR4R5; R3is H, F or C1-7alkoxy; R4and R5together with N are a 5- or 6-membered heterocyclic moiety having 1-3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur in which sulfur may be substituted by one (1) or two (2) oxygen atoms; and pharmaceutically acceptable salts thereof Compounds of formula I of the present invention are useful as antiviral agents.
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(2008/06/13)

Quinolinecarboxamides as antiviral agents
The present invention provides a compound of formula I which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.
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(2008/06/13)

Orthoamides. LIV. Contributions to the chemistry of azavinylogous orthoformic acid amide derivatives
The azavinylogous aminalester 3 reacts with primary amines to give amidines 5 and 6. In the reaction of 3 with aniline the azavinylogous amidine 7 is produced additionally to the amidine 5c. Ethylendiamine is formylated at both aminogroups, the bis-amidine 8 thus formed is transformed to the salts 9a,b. Benzoxazole and benzimidazole can be prepared from 3 and o-aminophenol and o-phenylenediamine, resp. Carboxylic acid amides, urea, thiourea, aromatic acid hydrazides 17 and the sulfonylhydrazide 19 are formylated by 3 at nitrogen to give N-acylated formamidines 14, 16, 18, 20. From 3 and aliphatic acid hydrazides 17 and alkylhydrazines, resp., can be obtained 1,2,4-triazole 21 and 1-alkyl-1,2,4-triazoles 22a,b, resp. N.N-Dimethylcyanacetamide (32) reacts with 3 and the orthoamide 4a, resp., to give a mixture of the formylated compound 34 and the amidine 33. The reaction conditions are of low influence on the ratio in which 33 and 34 are formed. The orthoamide 4b and 32 react to afford a mixture of the amidine 35 and the enamine 36. Hydrogen-sulfide acts on 3 giving N,N-dimethylthioformamide (37). From 3 and 1-alkynes 41 can be prepared the amidines 42. Hydrolysis of 42b affords phenylpropiolaldehyde (43). The alkylation of the aminalester 3 gives rise to the formation of vinylogous amidinium salts 1c and 1d, resp., additionally is formed the amide acetal 2a. The salt 1d can also be prepared from 3 and borontrifluoride-ether. Iodide reacts with N,N-dimethylformamide acetals 12a,b in an unclear, complicated manner giving orthoesters 53, N,N-dimethylformamide, alkyliodides, alcohols, ammonium iodides 46 and carbondioxide. The action of halogens on 3 affords the salts 1a,b,c,e,f depending on the chosen stoichiometric ratio. Aromatic aldehydes are suited for trapping azavinylogous carbenes formed on thermolysis of 3; 1,3-oxazoles 69 are the reaction products. From 3 and propionaldehyde the amidine 65 can be obtained with low yield. Carbondisulfide transforms 3 to the azavinylogous salt 66. The preparation of the azavinylogous orthoamide 4a is described. The thermolysis of 3 and 4a, resp., gives rise to the formation of the triaminopyrimidine 67. Treatment of 1a with lithium diisopropylamide affords the triaminopyrazine 68, which can also be obtained by thermolysis of 3 in the presence of sodium hydride. Azavinylogous carbenes are thought to be the intermediates. Wiley-VCH Verlag GmbH, 2000.
Kantlehner, Willi,Hauber, Michael,Haug, Erwin,Schallenmueller, Claus,Regele, Claudia
p. 682 - 699
(2007/10/03)

Use of xanthine oxidase inhibitors as anti-ischaemic agents
The use of a compound of formula I STR1 in which R1 and R2 are N, X1 and X2 which may be the same or different are hydrogen, hydroxy, or an optionally substituted alkyl, and Z1 and Z2 which may be the same or different are hydrogen, hydroxy, keto (=O), or one of Z1 and X1 and Z2 and X2 form a second bond of a double bond at the 1,6 or 2,3 positions with the proviso that at least one of the groupings R1 Z1 X1 R2 Z2 X2 and R1 X1 Z2 form a hydroxamate moiety (--N(OH)C(=O)-- in which R1 and R2 is N, Z1 and/or Z2 is =O and X1 and/or X2 is OH or R1 is N, Z2 is =O and X1 is OH and B is a 5 or 6 membered ring of formula II or III STR2 in which R4, R5, R6, R7, R8, R9, and R10 which may be the same or different are CH or N with the proviso that ring B cannot contain more than 3 ring members which are nitrogen and the ring B may optionally be substituted with a physiologically acceptable organic or inorganic acid, for the manufacture of a medicament for use as an anti-ischaemic agent.
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(2008/06/13)

Synthesis of Phosphinic Acids from Hypophosphites. I. Acrylates as an Unsaturated Component
A method is developed for preparing asymmetric phosphinic acids from hypophosphites and α,β-unsaturated carboxy compounds. A series of new functionally substituted phosphinic acids are prepared.
Kurdyumova,Rozhko,Ragulin,Tsvetkov
p. 1852 - 1856
(2007/10/03)

Process for preparing diphenylamines
A process is described for preparing diphenylamines of the formula STR1 by oxybromination of a phenol ether compound using elemental bromine in the presence of hydrogen peroxide and of a catalyst to give a brominated phenol ether compound which is subsequently reacted with a formanilide compound to give the compound of the formula (1). The oxybromination reaction is a regioselective, environmentally friendly and cost-efffective method of preparing brominated aromatic compounds. The diphenylamines of the formula (1) are industrially useful intermediates for the production, for example of dyes, and in particular of color formers of the fluoran type for pressure- or heat-sensitive recording systems.
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(2008/06/13)

Synthesis and Application of α,ω-Bis(dialkylamino)oligooxaalkanes and Their Analogs as Phase-Transfer Catalysts in Heterogeneous Synthesis of Trialkyl Orthoformates
α,ω-Bis(dialkylamino)oligooxaalkanes, 1,8-bis(alkoxyamino)-3,6-dioxaoctanes, and 1,8-bis(diethylamino)-3,6-dioxaoctane N,N'-dioxide are efficient phase-transfer catalysts, the use of which ensures preparation in high yields of trialkyl orthoformates from chloroform and primary alcohols in the heterogeneous systems CH2Cl2-solid alkali metal hydroxide.
Shtamburg, V. G.,Skobelev, O. L.,Grinev, V. M.,Dmitrienko, A. D.,Pleshkova, A. P.,Pritykin, L. M.
p. 609 - 612
(2007/10/03)

Substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones
The invention relates to new substituted 4,5-diamino-1,2,4-triazol-3-(thi)ones of the general formula (I), STR1 in which R1 represents alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, arylthioalkyl, arylsulfinylalkyl, arylsulfonylalkyl, arylaminoalkyl, N-alkyl-arylaminoalkyl, alkoxycarbonylalkyl, alkoxycarbonylalkenyl, alkylaminoalkyl, dialkylaminoalkyl, in each case optionally substituted cycloalkyl, cycloalkylalkyl, cycloalkenyl or cycloalkenylalkyl, or optionally substituted heterocyclylalkyl, or in each case optionally substituted aralkyl, arylalkenyl, arylalkinyl, aroyl, aryl, aralkyloxy or aryloxy, for alkoxy, alkenyloxy or alkinyloxy, R2, R3, R4 and R5 are identical or different and independently of one another represent hydrogen, alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cyanoalkyl, alkoxyalkyl, alkylthioalkyl, in each case optionally substituted cycloalkyl, cycloalkylalkyl, aryl or aralkyl or in each case two of these radicals (R2 and R3 or R4 and R5) represent together alkanediyl and R5 can also represent alkoxy, X represents oxygen or sulphur and Y represents oxygen or sulphur, a plurality of processes and new intermediates for their preparation, and their use as herbicides and plant growth regulators.
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(2008/06/13)

Die photochemische Synthese von Feinchemikalien mit Sonnenlicht
Das Licht der Sonne kann in der Photochemie direkt zur Veraenderung chemischer Strukturen genutzt werden.Die spektrale Photonenverteilung der Sonne sowie die Diskontinuitaet der Einstrahlung durch den Tag-Nacht-Rhythmus und das Wetter sind Randparameter, an denen sich eine technische Nutzung orientieren muss.Ausgehend von der Beschreibung des photochemischen Potentials der Sonne und grundsaetzlicher Ueberlegungen zur Konzeption von mit Sonnenlicht betriebenen Photoreaktoren (kurz: solare Photoreaktoren) werden deren Realisierung in einer ersten Pilotanlage auf der Plataforma Solar de Almeria in Suedspanien sowie andere Aktivitaeten in diesem Bereich zusammenfassend dargestellt.An den experimentellen Daten photochemischer Versuche im Technikumsmassstab werden Moeglichkeiten, Grenzen und Entwicklungspotential der solaren Photochemie dargelegt.Die solare Photochemie ist nach unserer Ansicht eine Technik, die wegen des photochemischen Synthesepotentials, der Abfallvermeidung und der direkten Nutzung der Sonne als Primaerenergiequelle (in diesem Fall eigentlich als Reaktionspartner) einen Beitrag zur Chemie der Zukunft leisten koennte.
Esser, Peter,Pohlmann, Bettina,Scharf, Hans-Dieter
p. 2093 - 2108
(2007/10/02)

Imidazonaphthyridine derivatives
Disclosed are imidazonaphthyridine derivatives represented by formula (I) STR1 wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents STR2 wherein R2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R5) H--(CH2)n --R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6 R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.
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(2008/06/13)

Notice on a Reaction of Alcohols with the Phase Transfer Catalytic Dichlorocarbene System (Applications of Phase Transfer Catalysis, Part 36)
Primary aliphatic alcohols and HCCl3/NaOH/catalyst yield stereoisomeric 1,2-dialkoxytetrachlorocyclopropanes 4 and 5, benzyl and phenethyl alcohol give orthoformates (1).Compounds 4 suffer rearrangement/hydrolysis at 120 grad C yielding 3-alkoxy-2,3-dichloroacrylates. - Key words: 1,2-Dialkoxytetrachlorocyclopropanes, ortho Esters
Dehmlow, Eckehard V.,Neuhaus, Rainer
p. 796 - 798
(2007/10/02)

On the Formation of 1,1,2,3-Tetrachloro-2,3-diethoxycyclopropane in Phase Transfer Catalyzed Dichlorocyclopropanations
When phase transfer catalysed dichlorocyclopropanations are performed in commercial chloroform as reagent/solvent (50percent aq.NaOH/TEBA-Cl, 40 deg C), the title compound 4 (a single stereoisomer assumed to be trans) is produced from the ethanol present in chloroform as a stabiliser.Formation of 4 can be avoided by pre-extracting the chloroform with water.A reaction path for the formation of 4 is proposed.
Ruecker, Christoph
p. 2137 - 2139
(2007/10/02)

Derivatives of 1,3,5-Triazine : Part II - Reactions of Cyanuric Chloride, a New Condensing Agent
Cyanuric chloride, a new condensing agent, has been found to be useful in the preparation of acid chlorides, amides and esters in good yields from carboxylic acids, picryl chloride from picric acid, and in bringing about the pinacol rearrangment of substituted ethanediol derivatives and lactonization of (R)-(+)-ricinelaidic acid.Treatment of cyanuric chloride with ethanol and formamide at room temperature gives triethyl orthoformate in 28percent yield.
Lahoti, R. J.,Wagle, D. R.
p. 852 - 855
(2007/10/02)

On the Mechanism of Acetalization Reactions with Carboxamide-Dialkyl Sulfate Adducts; a New Method of Preparation of Orthocarboxylic Esters and of Cleavage of Carboxamides.
It is shown that the efficiency of carboxamide-dialkyl-sulfate adducts in acetalization reactions depends on their alkylation ability.A mechanism of acetal formation using orthoformates as acetalization reagents is proposed.Alcoholysis of carboxamide-dialkyl sulfate adducts 1b, 11, 13 affords orthocarboxylic esters.Carboxamides and carboxmorpholides react with dimethyl sulfate/methanol to give methyl esters.
Kantlehner, Willi,Gutbrod, Heinz-Dieter
p. 1677 - 1688
(2007/10/02)