- PYRROLOPYRIDAZINE DERIVATIVES
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The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
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- Synthesis of N-[2-(2-methylpropoxy)ethyl]-N-{2-[(4-methoxy) phenylmethylthio]phenyl}-1-pyrrolidineethanamine (E)-2-butenedioate (1:1) salt (CERM 12816): A potential anti-anginal drug
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CERM 12816, which was required for metabolic studies, was labelled with [14C] in the methylene carbon of the benzyl group. This involved eight steps starting from barium [14C] carbonate and 4-methoxyphenylmagnesium bromide, with a 20
- Mounetou, Emmanuelle,Poisson, Claude,Monteil, Andre,Madelmont, Jean-Claude
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p. 181 - 189
(2007/10/03)
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- Process for preparation of α-alkoxy acetic acids and their salts
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A process for producing an α-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give an alko
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- SULFURIC ACID CATALYZED DECARBONYLATION OF ALKOXYACETYL CHLORIDES
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Sulfuric acid catalyzes the decarbonylation of alkoxyacetyl chlorides to produce the corresponding chloromethyl alkyl ethers in fairly good yields.
- Basavaiah, D.,Rao, P. Dharma,Gowriswari, V. V. L.
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p. 1411 - 1414
(2007/10/02)
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