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CAS

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24166-13-0

CLOXAZOLAM is a benzodiazepine derivative characterized by its anxiolytic, hypnotic, and antihypertensive properties. It is primarily used as an anti-anxiety drug and is metabolized into the active metabolite Delorezepam (D230675). Due to its potential for misuse and dependence, CLOXAZOLAM is classified as a controlled substance.

24166-13-0 Suppliers

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  • 24166-13-0 Structure

  • Basic information

    1. Product Name: CLOXAZOLAM
    2. Synonyms: CLOXAZOLAM;10-Chloro-11b-(2-chlorophenyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one;10-Chloro-11b-(o-chlorophenyl)-2,3,7,11b-tetrahydro-oxazolo[3,2-d] [1,4]benzodiazepin-6(5H)-one;11b-tetrahydro-;Betavel;Cloxazolazepam;CS 370;cs370
    3. CAS NO:24166-13-0
    4. Molecular Formula: C17H14Cl2N2O2
    5. Molecular Weight: 349.21
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 24166-13-0.mol

  • Chemical Properties

    1. Melting Point: 202-204° (dec)
    2. Boiling Point: 172°C (rough estimate)
    3. Flash Point: 269.4 °C
    4. Appearance: /
    5. Density: 1.4125 (rough estimate)
    6. Vapor Pressure: 5.47E-11mmHg at 25°C
    7. Refractive Index: 1.6100 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 12.70±0.40(Predicted)
    11. CAS DataBase Reference: CLOXAZOLAM(CAS DataBase Reference)
    12. NIST Chemistry Reference: CLOXAZOLAM(24166-13-0)
    13. EPA Substance Registry System: CLOXAZOLAM(24166-13-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. RIDADR: 3249
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 6.1(b)
    8. PackingGroup: III
    9. Hazardous Substances Data: 24166-13-0(Hazardous Substances Data)

24166-13-0 Usage

Uses

Used in Pharmaceutical Industry:
CLOXAZOLAM is used as an anxiolytic agent for the treatment of anxiety disorders. It helps in alleviating symptoms such as excessive worry, tension, and nervousness by modulating the neurotransmitter activity in the brain.
Used in Sleep Aid Applications:
CLOXAZOLAM is used as a hypnotic agent to treat insomnia and other sleep disorders. Its sedative effects promote relaxation and facilitate sleep onset, improving sleep quality and duration.
Used in Antihypertensive Applications:
CLOXAZOLAM is used as an antihypertensive agent to manage high blood pressure. It helps in reducing the stress response and lowering the heart rate, thereby contributing to the regulation of blood pressure.
Used in Controlled Substances Regulation:
As a controlled substance, CLOXAZOLAM is used in the regulation and monitoring of its distribution, prescription, and consumption. This classification aims to prevent misuse, dependence, and diversion of the drug for illicit purposes.

Originator

Sepazon,Sankyo,Japan,1974

Manufacturing Process

As described in US Patent 3,772,371: To a solution of 5.8 g of 5-chloro-2- bromoacetylamino-o-chlorobenzophenone in 120 ml of ethanol were added 0.95 g of ethanolamine and 1.3 g of sodium acetate. The resulting mixture was heated under reflux for 16 hours. After completion of the reaction, the solvent was distilled off and the residue was extracted with dichloromethane. The extract was washed with water, dried over anhydrous sodium sulfate and the solvent was distilled off to give 3.25 g of the desired product melting at 202° to 204°C with decomposition.

Therapeutic Function

Tranquilizer

Check Digit Verification of cas no

The CAS Registry Mumber 24166-13-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,6 and 6 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24166-13:
(7*2)+(6*4)+(5*1)+(4*6)+(3*6)+(2*1)+(1*3)=90
90 % 10 = 0
So 24166-13-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H14Cl2N2O2/c18-11-5-6-15-13(7-11)17(12-3-1-2-4-14(12)19)9-23-10-21(17)8-16(22)20-15/h1-7H,8-10H2,(H,20,22)

24166-13-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one

1.2 Other means of identification

Product number -
Other names Tolestan

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24166-13-0 SDS

24166-13-0Relevant articles and documents

Intermediates for tricyclic benzodiazepines

-

, (2008/06/13)

Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.