5504-92-7

Basic information

• Product Name: 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
• Synonyms: BDB;2-(2-BROMOACETAMIDO)-2',5-DICHLOROBENZOPHENONE;2-BROMOACETAMIDO-2',5-DICHLOROBENZOPHENONE;2-bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide;2-BROMACETAMINDO-2',5-DICHLORBENZOPHENON;2-BROMOACETAMIDO-2',5-DICHLOROBENZO-PHENONE (BDB);N-[2-(2-Chlorobenzoyl)-4-chlorophenyl]-α-bromoacetamide;2-bromo-N-[4-chloro-2-(2-chlorophenyl)carbonyl-phenyl]ethanamide
• CAS NO: 5504-92-7
• Molecular Formula: C₁₅H₁₀BrCl₂NO₂
• Molecular Weight: 387.06
• EINECS: 226-844-1
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;MTS & Sulfhydryl Active Reagents
• Mol File: 5504-92-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 574.5°Cat760mmHg
• Flash Point: 301.3°C
• Appearance: /
• Density: 1.628g/cm³
• Vapor Pressure: 3.33E-13mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 10.92±0.70(Predicted)
• Stability: Unstable in Solution, Moisture Sensitive
• CAS DataBase Reference: 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(5504-92-7)
• EPA Substance Registry System: 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide(5504-92-7)

Safety Data

• Hazardous Substances Data: 5504-92-7(Hazardous Substances Data)

Usage

Chemical Properties

White Crystals

Uses

2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide is used in the synthesis of Cloxazolam and its metabolites.

InChI:InChI=1/C15H10BrCl2NO2/c16-8-14(20)19-13-6-5-9(17)7-11(13)15(21)10-3-1-2-4-12(10)18/h1-7H,8H2,(H,19,20)

Upstream product

• 106-47-8 4-chloro-aniline 
• 609-65-4 o-chlorobenzoyl chloride 
• 598-21-0 2-Bromoacetyl bromide 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 

Downstream Products

• 56160-87-3 N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-2-morpholin-4-yl-acetamide 
• 56160-88-4 N-{4-chloro-2-[(2-chloro-phenyl)-(2-hydroxy-1-methyl-ethylimino)-methyl]-phenyl}-2-morpholin-4-yl-acetamide 
• 56160-89-5 4-[(4-Chloro-2-{(2-chloro-phenyl)-[(Z)-2-hydroxy-1-methyl-ethylimino]-methyl}-phenylcarbamoyl)-methyl]-4-methyl-morpholin-4-ium; iodide 
• 32711-07-2 10-chloro-11b-(2-chloro-phenyl)-2,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 32711-03-8 10-chloro-11b-(2-chloro-phenyl)-3,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24166-13-0 cloxazolam 
• 2894-68-0 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one 
• 2894-71-5 7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione 
• 28546-59-0 2-(methyl-thio)-5-(o-chlorophenyl)-7-chloro-3H-1,4-benzodiazepine 
• 2894-67-9 delorazepam 
• 31868-18-5 mexazolam 
• 24143-21-3 10-chloro-11b-(2-chloro-phenyl)-2-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24111-67-9 (+/-)-5,2'-Dichlor-2--benzophenon 
• 24234-92-2 N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide 

Relevant articles and documents

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Axially chiral Ni(II) complexes of α-amino acids: Separation of enantiomers and kinetics of racemization

Herein we present design, synthesis, chiral HPLC resolution, and kinetics of racemization of axially chiral Ni(II) complexes of glycine and di-(benzyl)glycine Schiff bases. We found that while the ortho-fluoro derivatives are configurationally unstable, t