5504-92-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide is used as an intermediate in the synthesis of Cloxazolam and its metabolites. Cloxazolam is a benzodiazepine derivative that possesses anxiolytic, sedative, and muscle relaxant properties, making it a valuable compound in the pharmaceutical industry for the treatment of anxiety and related disorders.
Chemical Properties:
2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide is described as white crystals, indicating its solid state at room temperature and its appearance. The chemical properties of 2-Bromo-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide contribute to its reactivity and utility in the synthesis of Cloxazolam and related compounds.

InChI:InChI=1/C15H10BrCl2NO2/c16-8-14(20)19-13-6-5-9(17)7-11(13)15(21)10-3-1-2-4-12(10)18/h1-7H,8H2,(H,19,20)

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 2958-36-3 (2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone 
• 106-47-8 4-chloro-aniline 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 56160-87-3 N-[4-chloro-2-(2-chloro-benzoyl)-phenyl]-2-morpholin-4-yl-acetamide 
• 24234-92-2 N-(2-hydroxy-ethyl)-glycine 4-chloro-2-(2-chloro-benzoyl)-anilide 
• 31868-18-5 mexazolam 
• 2894-67-9 delorazepam 
• 28546-59-0 2-(methyl-thio)-5-(o-chlorophenyl)-7-chloro-3H-1,4-benzodiazepine 
• 2894-71-5 7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione 
• 56160-88-4 N-{4-chloro-2-[(2-chloro-phenyl)-(2-hydroxy-1-methyl-ethylimino)-methyl]-phenyl}-2-morpholin-4-yl-acetamide 
• 56160-89-5 4-[(4-Chloro-2-{(2-chloro-phenyl)-[(Z)-2-hydroxy-1-methyl-ethylimino]-methyl}-phenylcarbamoyl)-methyl]-4-methyl-morpholin-4-ium; iodide 
• 2894-68-0 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one 
• 24166-13-0 cloxazolam 
• 32711-03-8 10-chloro-11b-(2-chloro-phenyl)-3,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 32711-07-2 10-chloro-11b-(2-chloro-phenyl)-2,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24143-21-3 10-chloro-11b-(2-chloro-phenyl)-2-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one 
• 24111-67-9 (+/-)-5,2'-Dichlor-2--benzophenon 

Relevant academic research and scientific papers

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Amide-Based Cinchona Alkaloids as Phase-Transfer Catalysts: Synthesis and Potential Application

Herein we present a library of simple amide derivatives of Cinchona alkaloids in the form of quaternary ammonium salts. The obtained derivatives can be generated very easily and efficiently from inexpensive and commercially available substrates. We tested this class of alkaloids in the alkylation of glycine derivative, carried out under phase-transfer catalyst conditions. The presented hybrid catalysts offer both high reaction yields (up to 97%) and high enantioselectivities of the obtained product (up to 94% ee).

Axially chiral Ni(II) complexes of α-amino acids: Separation of enantiomers and kinetics of racemization

Herein we present design, synthesis, chiral HPLC resolution, and kinetics of racemization of axially chiral Ni(II) complexes of glycine and di-(benzyl)glycine Schiff bases. We found that while the ortho-fluoro derivatives are configurationally unstable, t

Synthesis and spectral properties of 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines

A series of twelve new 2-[(o- and p-substituted)aminophenyl]-3H-5-[(o- and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines, which have possible pharmacological properties has been obtained. The synthesis was carried out following six steps. The structure of all products was corroborated by ir, 1H nmr, 13C nmr and ms. In addition for the compound 2-(o-chloroaminophenyl)-3H-5-(o-fluorophenyl)-7-chloro-1,4-benzodiazepine 7, its structure was confirmed by X-ray diffraction.