- Preparation method of ceftezole sodium
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The invention discloses a preparation method of ceftezole sodium, and belongs to the technical fields of pharmaceutical synthesis and refining. According to the method, 2-mercapto-1,3,4-thiadiazole and 7-aminocephalosporanic acid(ACA) are adopted to react and prepare an intermediate 1; and the obtained intermediate 1 reacts with tetrazolium anhydride(an intermediate 2) for acidation, salifying andrefining to prepare and obtain the ceftezole sodium. The preparation method provided by the invention is simple in operation, mild in reaction conditions, relatively high in yield and purity, low incontents of maximum single impurities and moisture and suitable for industrial production.
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Paragraph 0024; 0025; 0026; 0032; 0033; 0034; 0040-0042
(2019/03/06)
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- Ceftezole acid acylation reaction process
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Belonging to the field of medical technology, the invention discloses a ceftezole acid acylation reaction process. The method includes: subjecting pre-prepared intermediate 1 and intermediate 2 to acylation reaction at low temperature. An acylation reaction device adopted by the invention is mainly composed of a stirring unit, a cooling coil, a stirring paddle, an electromagnetic valve, a controller and a temperature sensor. The acylation reaction process provided by the invention is simple, achieves accurate control of the reaction temperature, increases the product yield, and reduces by-product generation.
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Paragraph 0025-0026; 0033
(2019/04/10)
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- Process for the preparation of solutions of 7-aminocephalosporanic acids
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A process for the preparation of solutions of 7-aminocephalosporanic acids wherein there is obtained a salt of the general formula III: STR1 where R1 may be a group selected from among hydrogen, methyl, or a low molecular weight alkoxy, R2 is a group selected from among methyl, methoxy, azido, chlorine, carbamoylmethyl, acetoxy, thiomethyl, phenylthiomethyl and others, x means from 3 to 5 carbon atoms and y means from 2 to 4 carbon atoms is disclosed. The process is based on the reaction of a compound of formula I STR2 with a bicyclic amidine.
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- Cephalosporin antibiotics
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Novel cephalosporin antibiotic derivatives.
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- Cephalosporin antibiotics
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Novel cephalosporin antibiotic derivatives.
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- Cephalosporin antibiotics
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Novel cephalosporin antibiotic derivatives.
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- Isothiourea substituted cephalosporin derivatives
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Novel cephalosporin and penicillin antibiotic derivatives.
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