243139-67-5

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)-4-METHYLANILINE
• Synonyms: 3,5-BIS(TRIFLUOROMETHYL)-4-METHYLANILINE;4-Amino-2,6-bis(trifluoromethyl)toluene;4-Methyl-3,5-bis(trifluoroMethyl)aniline
• CAS NO: 243139-67-5
• Molecular Formula: C₉H₇F₆N
• Molecular Weight: 243.15
• Mol File: 243139-67-5.mol

Chemical Properties

• Boiling Point: 190.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.389±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.58±0.10(Predicted)
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)-4-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)-4-METHYLANILINE(243139-67-5)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)-4-METHYLANILINE(243139-67-5)

Safety Data

• Hazard Codes: Xn
• Hazardous Substances Data: 243139-67-5(Hazardous Substances Data)

Upstream product

• 121-43-7 Trimethyl borate 
• 268733-18-2 4-bromo-3,5-bis(trifluoromethyl)benzenamine 
• 328-74-5 3,5-Bis-(trifluoromethyl)aniline 
• 823-96-1 Trimethylboroxine 

Downstream Products

• 1417658-24-2 5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide 

Relevant articles and documents

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TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.

Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling

A series of salicylanilides was synthesized based on a high-throughput screening hit against Mycobacterium tuberculosis. A free phenolic hydroxyl on the salicylic acid moeity is required for activity, and the structure-activity relationship of the aniline ring is largely driven by the presence of electron withdrawing groups. We synthesized 94 analogs exploring substitutions of both rings and the linker region in this series and we have identified multiple compounds with low micromolar potency. Unfortunately, cytotoxicity in a murine macrophage cell line trends with antimicrobial activity, suggesting a similar mechanism of action. We propose that salicylanilides function as proton shuttles that kill cells by destroying the cellular proton gradient, limiting their utility as potential therapeutics.