268733-18-2 Usage
Uses
4-Bromo-3,5-bis(trifluoromethyl)aniline was used to synthesize 2-hydroxydiarylamide derivatives for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. It was also used to synthesize salicylanilides with lantitubercular activities.
Check Digit Verification of cas no
The CAS Registry Mumber 268733-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,8,7,3 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 268733-18:
(8*2)+(7*6)+(6*8)+(5*7)+(4*3)+(3*3)+(2*1)+(1*8)=172
172 % 10 = 2
So 268733-18-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H4BrF6N/c9-6-4(7(10,11)12)1-3(16)2-5(6)8(13,14)15/h1-2H,16H2
268733-18-2Relevant articles and documents
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors
Kang, Sunghyun,Min, Hye-Jin,Kang, Min-Seo,Jung, Myung-Geun,Kim, Semi
, p. 1748 - 1751 (2013/04/10)
TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.