243977-15-3

Basic information

• Product Name: 4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE
• Synonyms: 8-(TRIFLUOROMETHYL)QUINOLIN-4-YLAMINE;4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE;BUTTPARK 10\01-47;8-(trifluoroMethyl)quinolin-4-aMine
• CAS NO: 243977-15-3
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.17
• Mol File: 243977-15-3.mol

Chemical Properties

• Boiling Point: 329.7 °C at 760 mmHg
• Flash Point: 153.2 °C
• Appearance: white powder
• Density: 1.39 g/cm³
• Vapor Pressure: 0.000175mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.75±0.50(Predicted)
• CAS DataBase Reference: 4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE(243977-15-3)
• EPA Substance Registry System: 4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE(243977-15-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 243977-15-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can contribute to the development of drugs with specific therapeutic properties.
Used in Rubber Industry:
In the rubber industry, 4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE is used as a chemical additive to enhance the properties of rubber materials. It can improve the durability, flexibility, and resistance to various environmental factors, such as heat and UV radiation.
Used in Antimicrobial Applications:
4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE is used as an antiseptic agent, helping to prevent the growth of harmful microorganisms and maintain cleanliness in various settings, such as medical facilities and personal care products.
Used in Antipyretic and Antiperiodic Applications:
4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE is also utilized in the development of antipyretic drugs, which are designed to reduce fever and alleviate discomfort associated with high body temperature. Additionally, it is used in the synthesis of antiperiodic drugs, which are effective in treating conditions like malaria.
Used in Antimalarial Applications:
4-AMINO-8-(TRIFLUOROMETHYL)QUINOLINE is used as an antimalarial agent, playing a crucial role in the development of drugs that target and eliminate the Plasmodium parasite responsible for malaria. It is also used in the preparation of other antimalarial drugs, contributing to the global fight against this life-threatening disease.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)7-3-1-2-6-8(14)4-5-15-9(6)7/h1-5H,(H2,14,15)

Upstream product

• 1161941-01-0 4-iodo-8-(trifluoromethyl)quinoline 

Downstream Products

• 1310549-99-5 C₁₉H₁₇F₃N₄O 

Relevant articles and documents

In situ generation of ammonia for the copper-catalyzed synthesis of primary aminoquinolines

The synthesis of primary aminoquinolines from iodoquinolines was carried out in the presence of copper(i) iodide and formamide as the solvent and source of ammonia generated in situ. The reaction proceeded under mild conditions within a few hours and was applicable to various iodoquinolines.