244-69-9

Basic information

• Product Name: gamma-carboline
• Synonyms: gamma-carboline;g-Carboline;5H-pyrido[4,3-b]indole;pyrido[4,3-b]indole;3-Azacarbazole;NSC 160470;3-PI;5H-Pyrido[4,3-b]indole
• CAS NO: 244-69-9
• Molecular Formula: C₁₁H₈N₂
• Molecular Weight: 168.198
• Mol File: 244-69-9.mol

Chemical Properties

• Melting Point: 230-231℃ (methanol water )
• Boiling Point: 391.3°Cat760mmHg
• Flash Point: 182.1°C
• Appearance: /
• Density: 1.352
• Vapor Pressure: 5.62E-06mmHg at 25°C
• Refractive Index: 1.664 (589.3 nm 25℃)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 15.08±0.30(Predicted)
• Merck: 14,1805
• CAS DataBase Reference: gamma-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: gamma-carboline(244-69-9)
• EPA Substance Registry System: gamma-carboline(244-69-9)

Safety Data

• Hazardous Substances Data: 244-69-9(Hazardous Substances Data)

Usage

Purification Methods

Crystallise it from water or EtOAc. [Robinson & Thornley J Chem Soc 12S 2169 1924, Dalton et al. Aust J Chem 22 185 1969, Staab & Wendel Org Synth 48 44 1968, Beilstein 23 II 223, 23 III/IV 1572.]

InChI:InChI=1/C11H8N2/c1-2-4-10-8(3-1)9-7-12-6-5-11(9)13-10/h1-7,13H

Upstream product

• 856849-78-0 3-(2-azidophenyl)pyridine 
• 91-17-8 decalin 
• 109073-14-5 1-(3-nitro-4-pyridyl)-benzo-1,2,3-triazole 
• 27246-81-7 3-bromophenylhydrazine hydrochloride 
• 622-88-8 4-bromophenylhydrazine hydrochloride 

Downstream Products

• 61406-19-7 5-methyl-5H-pyrido[4,3-b]indole 
• 66570-76-1 γ-carboline 2-oxide 
• 6208-60-2 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 5094-12-2 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 6208-43-1 2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 79642-24-3 8-amino-γ-carboline 
• 1059707-21-9 4-(biphenyl-4-yl)-6-[4-(5H-pyrido[4,3-b]indol-5-yl)phenyl]-[2,2']bipyridine 
• 1059707-24-2 6-(biphenyl-4-yl)-4-[4-(5H-pyrido[4,3-b]indol-5-yl)phenyl]-[2,2']bipyridine 
• 1175050-86-8 5-(3-bromophenyl)-5H-pyrido[4,3-b]indole 
• 1181387-68-7 4'-(4-bromophenyl)-6-(5H-pyrido[4,3-b]indol-5-yl)-[2,2';6',2'']terpyridine 
• 1181387-73-4 4'-(biphenyl-2-yl)-6-(5H-pyrido[4,3-b]indol-5-yl)-[2,2';6',2'']terpyridine 
• 1295596-92-7 8-benzoyl-2, 5-diethyl-γ-carboline-3-ium bromide 
• 1295596-95-0 8-(4-bromobenzoyl)-2, 5-diethyl-γ-carboline-3-ium bromide 
• 1219907-26-2 9,10-diphenyl-2-(5H-pyrido[4,3-b]indol-5-yl)anthracene 

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Relevant articles and documents

Microwave-enhanced Fischer reaction: An efficient one-pot synthesis of γ-carbolines

γ-Carbolines were obtained in a simple one-pot Fischer reaction starting from N-acetyl-3-bromo-4-piperidone hydrobromide and substituted arylhydrazine hydrochlorides in acidic media under microwave irradiation or by a thermal process. The optimization procedures are reported in detail, and the results from microwave processes are compared with conventional ones. Georg Thieme Verlag Stuttgart.

FLASH-VACUUM PYROLYSIS OF NITROARYLBENZOTRIAZOLES. A TANDEM MASS SPECTROMETRY STUDY

Tandem mass spectrometry (MS/MS) has been applied to investigate the behaviour of 1-(2-nitrophenyl)benzotriazole upon flash-vacuum pyrolysis (FVP) conditions.Above 500 deg C, is pyrolyzed to give a mixture of 1-nitrocarbazole , 1-hydroxycarbazole and carbazole .Under similar conditions, 2-(2-nitrophenyl)benzotriazole appears to be more stable; it is however partially isomerized into 8 at high temperatures.Aza analogs of 8, like 1-(2-nitro-4-pyridyl)benzotriazole also loose nitrogen above 500 deg C to give a mixture of 1-nitro-3-azacarbazole , 1-hydroxy-3-azacarbazole and 3-azacarbazole .