61406-19-7

Upstream product

• 27421-51-8 1-methyl-1H-indole-2-carboxaldehyde 
• 29124-06-9 1-methyl-2-vinyl-1H-indole 
• 244-69-9 γ-carboline 
• 616-38-6 carbonic acid dimethyl ester 
• 156137-02-9 2-bromo-1-methyl-1H-indole-3-carboxyaldehyde 
• 474267-19-1 1-methyl-2-(triethylsilylethynyl)indole-3-carboxaldehyde 
• 474267-20-4 2-(1-hydroxycyclohexylethynyl)-1-methylindole-3-carboxaldehyde 

Downstream Products

• 1158628-38-6 8-benzoyl-5-methyl-γ-carboline 

Relevant academic research and scientific papers

Efficient synthetic route toward biologically active γ-carboline derivatives

An efficient and short route was established for the synthesis of anti-bovine viral diarrhea virus agents, namely 4-methyl-γ-carboline (SK4M) 1, 3-methyl-γ-carboline (SK3M) 2, 5-methyl-γ-carboline (SK5M) 3, and a new γ-carboline derivative 4, using therma

γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.

Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and cyclization of terminal acetylenes

A variety of 3-substituted β- and γ-carbolines have been synthesized from N-substituted 3-iodoindole-2-carboxaldehydes and 2-bromoindole-3-carboxaldehydes, respectively. The coupling of these aldehydes with various terminal acetylenes with PdCl2(PPh3)2/CuI as the catalyst readily affords the corresponding alkynylindole carboxaldehydes, which have subsequently been converted to the corresponding tert-butylimines and cyclized to β- and γ-carbolines by either copper-catalyzed or thermal processes.

Lactam Acetals as Potential Enamine Synthons in Heterocyclic Synthesis, 4-th Communication. One Step Synthesis of the γ-Carboline Frame via Diels-Alder Reaction of Indol-"Ketene-N,O-Acetals"

2-Alkoxy-indoles 2a, b can be regarded as cyclic ketene-N,O-acetals.Their regiospecific -Diels-Alder reaction with inverse electron demand with the triazine 3 yield in a one step addition the γ-carboline (4). - Keywords: Lactam Acetals, Heterocyclic Synthesis, Cycloaddition Reactions, γ-Carbolines