- Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones
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Molecules with potent estrogenic activity are ~270 A3 hydrophobic structures that encompass two hydroxyls among which is at least one phenol. However, compounds with only one phenol or devoid of such a ring have been shown to enhance ERα-mediat
- Jacquot, Yves,Byrne, Cillian,Xicluna, Alain,Leclercq, Guy
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- BF3·OEt2-Mediated Tandem Annulation: A Strategy to Construct Functionalized Chromeno- and Pyrano-Fused Pyridines
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A simple and efficient one-pot annulation of arylidenones, alkynes, and nitriles in the presence of BF3·OEt2 is described. A highly functionalized variety of N-substituted pyridine-fused chromeno and pyrano derivatives were obtained
- Ashitha,Praveen Kumar,Fathimath Salfeena,Sasidhar
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p. 113 - 124
(2018/02/19)
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- A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases
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A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14 containing benzo[4,5]furo[3,2-b]pyridine core and 15 comprising chromeno[4,3-b]pyridine core, were synthesized, and their biological activities were evaluated. 3-(4-Ph
- Kwon, Han-Byeol,Park, Chanmi,Jeon, Kyung-Hwa,Lee, Eunyoung,Park, So-Eun,Jun, Kyu-Yeon,Kadayat, Tara Man,Thapa, Pritam,Karki, Radha,Na, Younghwa,Park, Mi Sun,Rho, Seung Bae,Lee, Eung-Seok,Kwon, Youngjoo
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p. 1100 - 1122
(2015/03/04)
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- Discovery of 3,3a,4,5-tetrahydro-2H-benzo[g]indazole containing quinoxaline derivatives as novel EGFR/HER-2 dual inhibitors
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In the present study, twenty-five pyrazole-quinoxaline derivatives (4a-4y) were designed and synthesized, and their biological activity as potential EGFR or HER-2 kinase inhibitors was evaluated. Among them, compound 4l displayed better antiproliferative
- Zong, Xi,Cai, Jin,Chen, Junqing,Sun, Chunlong,Li, Lushen,Ji, Min
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p. 24814 - 24823
(2015/03/30)
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- Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship
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Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well a
- Thapa, Uttam,Thapa, Pritam,Karki, Radha,Yun, Minho,Choi, Jae Hun,Jahng, Yurngdong,Lee, Eunyoung,Jeon, Kyung-Hwa,Na, Younghwa,Ha, Eun-Mi,Cho, Won-Jea,Kwon, Youngjoo,Lee, Eung-Seok
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experimental part
p. 3201 - 3209
(2011/07/31)
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- Novel α-hydroxyphosphonates - Enol phosphates rearrangement
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CsF was found to be a very efficient basic catalyst for the rearrangement of α-hydroxy-β,γ-epoxy(aziridino)phosphonates to enol phosphates. DBU and potassium fluorides (anhydrous or dihydrate) appeared less active in promoting this rearrangement, but strong enough to execute the retro-Abramov reaction. Because of the competition from the retro-Abramov reaction, stereochemistry of the rearrangement cannot be unequivocally assigned, but it seems reasonable that intermediates having the dimethoxy-phosphoryl group and O-epoxide or N-aziridine atoms as leaving groups in the antiperiplanar positions are involved.
- Wroblewski,Karolczak
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p. 1191 - 1202
(2007/10/03)
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- Synthesis and conformational analysis of some spiropyrazoline isomers
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A series of spiropyrazolines has been synthesized by 1,3-dipolar cycloaddition of E- and Z-3-arylidene-chromanones, -1-thiochromanones, -flavanones, -1-thioflavanones as well as 2-benzylidene-1-indanone, -1-benzosuberone with diazomethane. It has been found that this cycloaddition is regio- and stereoselective affording trans- and cis- spiro-1-pyrazolines. Spiro-1-pyrazolines were converted into spiro-2-pyrazolines on acid-catalysed isomerization. Conformation and relative configuration of compounds prepared has been elucidated by various one- and two-dimensional n.m.r. methods.
- Toth, Gabor,Levai, Albert,Szoellosy, Aron,Duddeck, Helmut
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p. 863 - 880
(2007/10/02)
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