Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through
Preston Pugh,Pouncey, Dakota L.,Hartman, Jessica H.,Nshimiyimana, Robert,Desrochers, Linda P.,Goodwin, Thomas E.,Boysen, Gunnar,Miller, Grover P.
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