246516-38-1

Basic information

• Product Name: 1H-Indene-1,3(2H)-dione, 2,2-bis(4-hydroxyphenyl)-
• Synonyms: 2,2-di(4-hydroxyphenyl)indane-1,3-dione;1H-Indene-1,3(2H)-dione,2,2-bis(4-hydroxyphenyl);2,2'-bis(4-hydroxyphenyl)-1,3-indanedione
• CAS NO: 246516-38-1
• Molecular Formula: C21H14O4
• Molecular Weight: 330.33300
• Mol File: 246516-38-1.mol

Chemical Properties

• CAS DataBase Reference: 1H-Indene-1,3(2H)-dione, 2,2-bis(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-1,3(2H)-dione, 2,2-bis(4-hydroxyphenyl)-(246516-38-1)
• EPA Substance Registry System: 1H-Indene-1,3(2H)-dione, 2,2-bis(4-hydroxyphenyl)-(246516-38-1)

Safety Data

• Hazardous Substances Data: 246516-38-1(Hazardous Substances Data)

Upstream product

• 485-47-2 indan-1,2,3-trione hydrate 
• 108-95-2 phenol 
• 938-24-9 indantrione 

Downstream Products

• 786681-06-9 2,2-bis-[4-(4-bromomethyl-benzyloxy)-phenyl]-indan-1,3-dione 
• 786681-04-7 2,2-bis-[4-(4'-chloromethyl-biphenyl-4-ylmethoxy)-phenyl]-indan-1,3-dione 
• 786681-11-6 C₇₉H₅₄O₁₂ 

Relevant articles and documents

The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the ortho selectivity of ninhydrin-phenol adducts

Although ninhydrin is an essential analytical tool in biochemical and forensic sciences, for the past several years, it has been employed as efficient building block for diverse organic scaffolds. In the present work, the ortho selectivity of ninhydrin-phenol adducts has been exploited to obtain 2-(2′-hydroxyaryl)benzimidazoles which are well known excited state intramolecular proton transfer (ESIPT) fluorophores. Under acidic condition, 3-(2-hydroxyaroyl)isoindolin-1-one intermediate generated in situ from ninhydrin-phenol adducts was treated with o-phenylenediamine resulting benzimidazole scaffolds via a two-step one pot strategy.

Design and synthesis of ninhydrin-based cyclophanes as potential neutral receptors for quaternary ammonium cations

Four ninhydrin-based cyclophanes 4a, 4b, 6a, and 6b were designed and synthesized. Two rectangular type cyclophanes (4a and 4b) and two square type cyclophanes (6a and 6b) were prepared in 8-43% yields.

Polycyclic aromatics from veratrole and ninhydrin and acenaphthenequinone

Treatment of 2,2-di(3,4-dimethoxyphenyl)indane-1,3-dione with concentrated sulfuric acid gives 2,3,6,7-tetramethoxydibenzo[a,c]fluoren-13-one while under the same conditions 2,2-di(3,4-dimethoxyphenyl)acenaphthenone produces 2,3,6,7-tetramethoxydibenzo[j,l]fluoranthene.

Friedel-Crafts type reactions of some activated cyclic ketones with phenol derivatives

Friedel-Crafts type reactions of phenol derivatives with some cyclic ketones such as ninhydrin (1), alloxan (2), isatin (3), and parabanic acid (4) were examined. 2-Monoaryl- and 2,2-diaryl-1,3-indanedione derivatives were obtained depending on the acid catalyst in the cases of ninhydrin and alloxan. In the case of isatin, the corresponding diarylated derivative was obtained as the sole product in high yields. Parabanic acid was unreactive under the reaction conditions.