- Preparation method of 2-amino-3-fluoropyridine
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The invention discloses a preparation method of 2-amino-3-fluoropyridine, wherein 2,3-difluoro-5-chloropyridine is employed as a raw material and is subjected to an ammoniation reaction with ammonia water, and then a reduction reaction is carried out to prepare the 2-amino-3-fluoropyridine. The preparation method is less in steps, is simple in operation, employs low-cost and easy-to-obtain raw materials, has simple after treatment and high yield and is 77.5% in total yield, and is suitable for large-scale preparation.
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Paragraph 0058; 0059; 0060
(2016/11/17)
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- Certain Chemical Entities, Compositions, and Methods
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Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.
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Page/Page column 34
(2008/12/07)
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- Process for preparing 2-aminopyridine derivatives
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A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.
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Page/Page column 4
(2008/06/13)
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