246847-98-3

Basic information

• Product Name: 2-Amino-5-chloro-3-fluoropyridine
• Synonyms: 2-Amino-5-chloro-3-fluoropyridine;2-Pyridinamine,5-chloro-3-fluoro-(9CI);5-Chloro-3-fluoropyridin-2-amine;2-Amino-5-chloro-3-fluoropyrid;5-Chloro-3-fluoro-2-pyridinamine;2-AMino-5-chloro-3-fluoropyridine;2-Amino-5-chloro-3-fluoropyridine 97%
• CAS NO: 246847-98-3
• Molecular Formula: C₅H₄ClFN₂
• Molecular Weight: 146.55
• EINECS: 253-700-5
• Product Categories: PYRIDINE;Amines;blocks;FluoroCompounds;Pyridines;Amines and Anilines;Heterocycles;Fluorine series
• Mol File: 246847-98-3.mol

Chemical Properties

• Melting Point: 95-97℃
• Boiling Point: 195.929 °C at 760 mmHg
• Flash Point: 72.295 °C
• Appearance: /
• Density: 1.45 g/cm³
• Vapor Pressure: 0.409mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.72±0.49(Predicted)
• CAS DataBase Reference: 2-Amino-5-chloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-chloro-3-fluoropyridine(246847-98-3)
• EPA Substance Registry System: 2-Amino-5-chloro-3-fluoropyridine(246847-98-3)

Safety Data

• Hazard Codes: T,Xi
• Statements: 23/24/25-50
• Safety Statements: 36/37-38-45-61-63
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 246847-98-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5-chloro-3-fluoropyridine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs with diverse biological activities and pharmacological properties.
Used in Agrochemical Industry:
2-Amino-5-chloro-3-fluoropyridine is utilized as an intermediate in the production of agrochemicals, playing a crucial role in the development of effective and environmentally friendly pesticides and other agricultural chemicals.
Used in Fine Chemicals Industry:
2-Amino-5-chloro-3-fluoropyridine serves as a building block for the preparation of various functionalized pyridines, which are essential components in the synthesis of fine chemicals with specific applications in different industries.
Used in Organic Synthesis:
As a versatile chemical entity, 2-Amino-5-chloro-3-fluoropyridine is employed in organic synthesis to create a wide range of functionalized pyridines, expanding the scope of chemical compounds available for various applications.
Used in Medicinal Chemistry and Drug Discovery:
Due to its diverse biological activities and pharmacological properties, 2-Amino-5-chloro-3-fluoropyridine has potential applications in the field of medicinal chemistry and drug discovery, aiding in the identification and development of novel therapeutic agents.

InChI:InChI=1/C5H4ClFN2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)

Upstream product

• 248255-70-1 5-chloro-3-fluoro-2-hydrazinylpyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 1064783-29-4 5-chloro-3-fluoro-2-nitropyridine 
• 1314514-82-3 3-fluoro-4-methyl-5-chloro-2-acetamidopyridine 
• 1033202-10-6 6-chloro-8-fluoroimidazo[1,2-a]pyridine 
• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 

Relevant articles and documents

Preparation method of 2-amino-3-fluoropyridine

The invention discloses a preparation method of 2-amino-3-fluoropyridine, wherein 2,3-difluoro-5-chloropyridine is employed as a raw material and is subjected to an ammoniation reaction with ammonia water, and then a reduction reaction is carried out to prepare the 2-amino-3-fluoropyridine. The preparation method is less in steps, is simple in operation, employs low-cost and easy-to-obtain raw materials, has simple after treatment and high yield and is 77.5% in total yield, and is suitable for large-scale preparation.

Certain Chemical Entities, Compositions, and Methods

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.

Process for preparing 2-aminopyridine derivatives

A method for preparing 2-aminopyridine derivatives, which comprises substituting of fluorine for hydrazine moiety and reducing with hydrogen using 3-substituted-2,5,6-trifluoropyridine as a starting material, provides 2-aminopyridine derivatives having a purity over 98% under a mild reaction condition.