247069-27-8

Basic information

• Product Name: 3,5-Difluoropyridine-2,6-diamine
• Synonyms: 2,6-DIAMINO-3,5-DIFLUOROPYRIDINE;3,5-DIFLUOROPYRIDINE-2,6-DIAMINE;2,6-Pyridinediamine, 3,5-difluoro- (9CI);3,5-Difluoropyiridine;2,6-Diamino-3,5-difluoropyridi;3,5-difluoro-2,6-PyridinediaMine;2,6-PyridinediaMine, 3,5-difluoro-
• CAS NO: 247069-27-8
• Molecular Formula: C₅H₅F₂N₃
• Molecular Weight: 145.11
• EINECS: 1312995-182-4
• Product Categories: AMINEPRIMARY;HALIDE;PYRIDINE;Amines;Pyridines;Heterocycle;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Fluorine series;Furans
• Mol File: 247069-27-8.mol

Chemical Properties

• Melting Point: 160°C
• Boiling Point: 233.265 °C at 760 mmHg
• Flash Point: 94.876 °C
• Appearance: /
• Density: 1.517 g/cm³
• Vapor Pressure: 0.056mmHg at 25°C
• Refractive Index: 1.602
• PKA: 1.93±0.10(Predicted)
• CAS DataBase Reference: 3,5-Difluoropyridine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoropyridine-2,6-diamine(247069-27-8)
• EPA Substance Registry System: 3,5-Difluoropyridine-2,6-diamine(247069-27-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 21/22-36/37-36
• Safety Statements: 24-26-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 247069-27-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Difluoropyridine-2,6-diamine is used as a reagent for the synthesis of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone, a compound with antimycobacterial and antibacterial activity. This application is significant in the development of new drugs to combat resistant strains of tuberculosis and other bacterial infections.
Used in Chemical Research:
Due to its unique structure and reactivity, 3,5-Difluoropyridine-2,6-diamine can also be employed in chemical research for the exploration of novel synthetic pathways and the development of new compounds with potential applications in various fields, including material science, agrochemistry, and pharmaceuticals.

InChI:InChI=1/C5H5F2N3/c6-2-1-3(7)5(9)10-4(2)8/h1H,(H4,8,9,10)

Upstream product

• 247069-28-9 N₂,N₆-dibenzyl-2,6-diamino-3,5-difluoropyridine 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 2176-62-7 2,3,4,5,6-pentachloropyridine 

Downstream Products

• 875712-88-2 (E)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 875712-88-2 (Z)-1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 875712-88-2 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 442526-91-2 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-isobutyryloxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester 

Relevant articles and documents

Direct di- and triamination of polyfluoropyridines in anhydrous ammonia

Aminodefluorination of polyfluoropyridines (pentafluoro-, 3,5-dichlorotrifluoro-, 3- and 4-chlorotetrafluoro-, 2,3,5,6- and 2,3,4,6-tetrafluoro-, 3-chloro-2,4,6-trifluoro-, and 2,4,6-trifluoropyridine) in anhydrous ammonia has been investigated. Temperatu

Preparation method of 3,5-difluoro-2,6-diaminopyridine

The invention discloses a preparation method of 3,5-difluoro-2,6-diaminopyridine, and belongs to the technical field of preparation methods of chemical drug intermediates. 2,3,4,5,6-pentachloropyridine is utilized as a raw material; and the 3,5-difluoro-2,6-diaminopyridine is prepared through reduction by a metallic reducing agent, fluorination and aminolysis. The method provided by the inventionis simple to operate, short in reaction time, environmentally friendly in process route and higher in yield, and has higher industrialization value; and an economical and high-efficiency catalyst is adopted.

Method for preparing 2,6-diamino-3,5-difluoropyridine

The invention discloses a method for preparing an intermediate of an anti-infectious new drug Delafloxacin, i.e., 2,6-diamino-3,5-difluoropyridine. The method comprises the steps of taking 2,3,5,6-tetrafluoropyridine as a raw material, and carrying out a

Selective mono-and diamination of polyfluorinated benzenes and pyridines with liquid ammonia

Amination of pentafluoropyridine, 2,3,5,6-tetrafluoropyridine, 4-chlorotetrafluoropyridine, 3,5-dichlorotrifluoropyridine, octafluorotoluene, α,α,α,2,3,5,6-heptafluorotoluene, decafluoro-m-xylene, decafluorobiphenyl, hexafluorobenzene, and pentafluorobenzene with liquid ammonia was investigated. Bis-aminodefluorination temperatures for the majority of substrates were shown to exceed significantly the corresponding temperatures of monoaminodefluorination. The optimal conditions for selective preparation of mono-and diaminopolyfluoro(het)arenes were elucidated. An efficient method for isolation of particular polyfluorophenylenediamines from product mixtures formed in nonselective reactions of pentafluorobenzene and hexafluorobenzene with aqueous ammonia based on complexation with a crown ether is proposed.

PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS

A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.