247228-28-0

Basic information

• Product Name: 3,4-(ETHYLENEDIOXY)THIOPHENOL
• Synonyms: 2,3-DIHYDRO-BENZO[1,4]DIOXINE-6-THIOL;3,4-(ETHYLENEDIOXY)THIOPHENOL
• CAS NO: 247228-28-0
• Molecular Formula: C₈H₈O₂S
• Molecular Weight: 168.21
• Mol File: 247228-28-0.mol

Chemical Properties

• Boiling Point: 88°C/0.1mm
• Appearance: /
• Density: 1.284±0.06 g/cm3(Predicted)
• PKA: 6.55±0.20(Predicted)
• CAS DataBase Reference: 3,4-(ETHYLENEDIOXY)THIOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-(ETHYLENEDIOXY)THIOPHENOL(247228-28-0)
• EPA Substance Registry System: 3,4-(ETHYLENEDIOXY)THIOPHENOL(247228-28-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 247228-28-0(Hazardous Substances Data)

Upstream product

• 57744-67-9 6-iodo-1,4-benzodioxane 
• 52287-51-1 6-bromo-1,4-benzodioxane 

Downstream Products

• 890847-39-9 1-[4-(2,3-dihydro-benzo[1,4]dioxin-6-ylsulfanylmethyl)-phenyl]-ethanone 
• 280751-14-6 (benzodioxan-6-yl)[2-trifluoromethyl-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide 
• 280751-90-8 (benzodioxan-6-yl)[2,3-dichloro-4-(E-((4-carboethoxypiperidin-1-yl)carbonyl)ethenyl)phenyl]sulfide 
• 280750-31-4 (benzodioxan-6-yl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide 
• 280753-25-5 2-trifluoromethyl-4-(thiobenzodioxan-6-yl)cinnamic acid 

Relevant articles and documents

SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

A highly efficient transition metal-catalyzed single-step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2-ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure - Activity relationship of substituents on the benzene ring of the cinnamide

We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We now show that 2,3-disubstitution on the aryl portion of the cinnamide results in enhanced activit