Cas 280750-31-4,1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine

280750-31-4

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Basic information

Product Name: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine
Synonyms: A-292949
CAS NO:280750-31-4
Molecular Formula: C₂₃H₂₃ClN₂O₄S
Molecular Weight: 458.96776
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(CAS DataBase Reference)
NIST Chemistry Reference: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(280750-31-4)
EPA Substance Registry System: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(280750-31-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 280750-31-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 280750-31-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,0,7,5 and 0 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 280750-31:
(8*2)+(7*8)+(6*0)+(5*7)+(4*5)+(3*0)+(2*3)+(1*1)=134
134 % 10 = 4
So 280750-31-4 is a valid CAS Registry Number.

280750-31-4Upstream product

280750-31-4Downstream Products

280750-31-4Relevant academic research and scientific papers

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

-

, (2008/06/13)

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

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Page 55, (2010/02/07)

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure - Activity relationship of substituents on the benzene ring of the cinnamide

Winn,Kester,Von Geldern,Leitza,Devries,Dickinson,Mussatto,Okasinski,Reilly,Liu,Huth,Jae,Freeman,Pei,Xin,Lynch

, p. 4393 - 4403 (2007/10/03)

We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We now show that 2,3-disubstitution on the aryl portion of the cinnamide results in enhanced activit

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

Liu,Huth,Olejniczak,Mendoza,DeVries,Leitza,Reilly,Okasinski,Fesik,von Geldern

, p. 1202 - 1210 (2007/10/03)

The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. Recently, a novel series of p-arylthio cinnamides has been described as potent

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