280750-31-4

Basic information

• Product Name: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine
• Synonyms: A-292949
• CAS NO: 280750-31-4
• Molecular Formula: C₂₃H₂₃ClN₂O₄S
• Molecular Weight: 458.96776
• Mol File: 280750-31-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(280750-31-4)
• EPA Substance Registry System: 1-Acetyl-4-[3-[3-chloro-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfanyl)phenyl]-2(E)-propenoyl]piperazine(280750-31-4)

Safety Data

• Hazardous Substances Data: 280750-31-4(Hazardous Substances Data)

Upstream product

• 280752-60-5 3-[4-[3-(4-acetyl-piperazin-1-yl)-3-oxo-propenyl]-2-chlorophenylsulfanyl]-propionic acid methyl ester 
• 341497-56-1 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester 
• 13889-98-0 N-acetylpiperidine 
• 247228-28-0 2,3-dihydrobenzo[b][1,4]dioxine-6-thiol 
• 52287-51-1 6-bromo-1,4-benzodioxane 
• 34328-61-5 3-Chloro-4-fluorobenzaldehyde 

Relevant articles and documents

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. Recently, a novel series of p-arylthio cinnamides has been described as potent