247592-71-8

Basic information

• Product Name: N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• Synonyms: N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE
• CAS NO: 247592-71-8
• Molecular Formula: C16H14ClNO4
• Molecular Weight: 319.74
• Mol File: 247592-71-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE(247592-71-8)
• EPA Substance Registry System: N-(3-CHLORO-PHENYL)-2-(4-FORMYL-2-METHOXY-PHENOXY)-ACETAMIDE(247592-71-8)

Safety Data

• Hazardous Substances Data: 247592-71-8(Hazardous Substances Data)

Upstream product

• 108-42-9 3-chloro-aniline 
• 121-33-5 vanillin 
• 17641-03-1 N-(3-chlorophenyl)-2-iodoacetamide 
• 2564-05-8 2-chloro-N-(3-chlorophenyl)acetamide 

Relevant articles and documents

Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors

Twenty novel 2-substituted quinoline-4-carboxylic acids bearing amide moiety were designed and synthesized by Doebner reaction. Human dihydroorotate dehydrogenase (hDHODH) was recognized as a biological target and all compounds were screened as potential hDHODH inhibitors in an enzyme inhibition assay. The prepared heterocycles were also evaluated for their cytotoxic effects on the healthy HaCaT cell line while lipophilic properties were considered on the basis of experimentally determined logD values at physiological pH. The most promising compound 5j, with chlorine at para-position of terminal phenyl ring, showed good hDHODH inhibitory activity, low cytotoxicity, and optimal lipophilicity. The bioactive conformation of 5j on the hDHODH, determined by means of molecular docking, revealed the compound's pharmacology and provide guidelines for further lead optimization.

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