250651-53-7

Basic information

• Product Name: Ethanone, 1-(1H-imidazo[4,5-b]pyridin-2-yl)- (9CI)
• Synonyms: Ethanone, 1-(1H-imidazo[4,5-b]pyridin-2-yl)- (9CI)
• CAS NO: 250651-53-7
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16068
• Product Categories: ACETYLGROUP
• Mol File: 250651-53-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(1H-imidazo[4,5-b]pyridin-2-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1H-imidazo[4,5-b]pyridin-2-yl)- (9CI)(250651-53-7)
• EPA Substance Registry System: Ethanone, 1-(1H-imidazo[4,5-b]pyridin-2-yl)- (9CI)(250651-53-7)

Safety Data

• Hazardous Substances Data: 250651-53-7(Hazardous Substances Data)

Upstream product

• 250651-52-6 2-(1-hydroxyethyl)-1H-imidazo[4,5-b]pyridine 
• 452-58-4 2,3-Diaminopyridine 

Downstream Products

• 497073-88-8 3-(4-chloro-phenyl)-1-(3H-imidazo[4,5-b]pyridin-2-yl)-propenone 
• 380639-53-2 1-(3H-imidazo[4,5-b]pyridin-2-yl)-3-phenyl-propenone 

Relevant articles and documents

Synthesis and antitumor activity of new thiosemicarbazones of 2-acetylimidazo[4,5-b]pyridine

A number of thiosemicarbazones of 2-acetyl-imidazo[4,5-b]pyridine were prepared in order to investigate their in vitro antineoplastic activities. Three compounds: (i) 2-acetylimidazo[4,5-b]pyridin-4-tert-butyl-3-thiosemicarbazone [(A7), NSC674098], (ii) 2-acetylimidazo[4,5-e]pyridin-4-tert-butyl-3- thiosemicarbazone [(A9), NSC674099], (iii) 2-acetylimidazo[4,5-i] pyridin-4-cyclohexyl-3-thiosemicarbozone [(A11), NSC674101] showed remarkable activity against some of the cell lines tested. The Biological Evaluation Committee of N.C.I, determined that further secondary testing should be carried out (these compounds were tested against prostate cancer).

Synthesis and some reactions of 2-acetylimidazo[4,5-b]pyridine. Antituberculotic activity of the obtained compounds

2-Acetylimidazo[4,5-b]pyridine was prepared and its reactions with some aromatic amines and sulfur (Willgerodt-Kindler reaction), some aromatic aldehydes, some carboxylic acid hydrazides as well as thiourea were investigated. New imidazo[4,5-b]pyridine derivatives with different substituents in 2-position (N-arylthioamides, imines, α β-unsaturated ketones, hydrazido-hydrazones and aminothiazole) were obtained. Most of the synthesized compounds were tested in vitro for their antituberculotic activity.