Novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: Chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration
Under pathophysiological conditions, α-amino-3-hydroxy-5-methyl-4- isoxazole propionate (AMPA) receptor activation is considered to play a key role in several disorders of the central nervous system. In the search for AMPA receptor antagonists, the synthe
CONDENSED 2,3-BENZODIAZEPINE DERIVATIVES AND THIER USE AS AMPA-RECEPTOR INHIBITORS
Compounds of formula I are described, their production and use in pharmaceutical agents.
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(2008/06/13)
Synthesis and anticonvulsant activity of novel and potent 2,3- benzodiazepine AMPA/kainate receptor antagonists
We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H- 2,3-benzodiazepin-4-ones (3) possess marked anticonvulsant properties and antagonize seizures induced by 2-amino-3-(3-hydroxy-5-methylisoxazol-4- yl)propionic acid (AMPA) in analogy t