251101-37-8

Basic information

• Product Name: 4-(5-Methylpyridin-2-yl)Morpholine
• Synonyms: 4-(5-Methylpyridin-2-yl)Morpholine
• CAS NO: 251101-37-8
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178
• Mol File: 251101-37-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5-Methylpyridin-2-yl)Morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Methylpyridin-2-yl)Morpholine(251101-37-8)
• EPA Substance Registry System: 4-(5-Methylpyridin-2-yl)Morpholine(251101-37-8)

Safety Data

• Hazardous Substances Data: 251101-37-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-(5-Methylpyridin-2-yl)Morpholine is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals for its ability to enhance the biological activity and selectivity of the final products.
Used in Organic Electronics and Optoelectronics:
4-(5-Methylpyridin-2-yl)Morpholine is utilized as a component in the development of organic electronic devices and optoelectronic materials due to its favorable electronic and optical properties, which can improve device performance and efficiency.
Used in Corrosion Inhibition:
4-(5-Methylpyridin-2-yl)Morpholine is employed as a corrosion inhibitor in various industrial applications to protect materials from degradation, extending their service life and reducing maintenance costs.

Upstream product

• 132546-81-7 methyl 6-morpholinonicotinate 
• 179400-16-9 5-methylpyridine-2-sulfonyl chloride 
• 110-91-8 morpholine 
• 2369-19-9 2-fluoro-5-methylpyridine 
• 110-89-4 piperidine 
• 3510-66-5 2-Bromo-5-methylpyridine 

Relevant articles and documents

Exhaustive Reduction of Esters Enabled by Nickel Catalysis

We report a one-step procedure to directly reduce unactivated aryl esters into their corresponding tolyl derivatives. This is achieved by an organosilane-mediated ester hydrosilylation reaction and subsequent Ni/NHC-catalyzed hydrogenolysis. The resulting conditions provide a direct and efficient alternative to multi-step procedures for this transformation that often require the use of hazardous metal hydrides. Applications in the synthesis of -CD3-containing products, derivatization of bioactive molecules, and chemoselective reduction in the presence of other C-O bonds are demonstrated.

Nickel-Catalyzed Intramolecular Desulfitative C - N Coupling: A Synthesis of Aromatic Amines

A nickel-catalyzed intramolecular C - N coupling reaction via SO2 extrusion is presented. The use of a catalytic amount of BPh3 allows the transformation to take place under much milder conditions (60 °C) than previously reported C - N coupling reactions by CO or CO2 extrusion (160-180 °C). In addition, this method displays good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines, and triaryl amines. The robustness of the desulfitative C - N coupling is demonstrated by three high-yielding gram-scale reactions.

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines, and Pharmaceuticals

Methods to incorporate deuterium and tritium atoms into organic molecules are valuable for medicinal chemistry. The prevalence of pyridines and diazines in pharmaceuticals means that new ways to label these heterocycles will present opportunities in drug design and facilitate absorption, distribution, metabolism, and excretion (ADME) studies. A broadly applicable protocol is presented wherein pyridines, diazines, and pharmaceuticals are converted into heterocyclic phosphonium salts and then isotopically labeled. The isotopes are incorporated in high yields and, in general, with exclusive regioselectivity.

Synthesis and structural characterization of palladium(II) thiosemicarbazone complex: Application to the Buchwald-Hartwig amination reaction

A simple route to synthesize mononuclear palladium(II) thiosemicarbazone complex has been described. Elemental analysis, spectral methods and single crystal X-ray diffraction analysis were used to confirm the composition of the complex. The new complex acts as an active homogeneous catalyst for the Buchwald-Hartwig amination reaction of a wide range of aryl and heteroaryl halides (bromides and chlorides), including activating, neutral and deactivating substrates, with various secondary amines under optimized conditions.