251349-56-1

Basic information

• Product Name: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride
• Synonyms: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride;(S)-2-Pyrrolidin-2-ylthiazole-4-carboxylic acid ethyl ester;R-Ethyl 2-(pyrrolidine-2-yl)thiazole-4-carboxylate hydrochloride;(S)-2-Pyrrolidin-2-ylthiazole-4-Carbocylic acid ethyl ester;(R)-ethyl 2-(pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride;ethyl (S)-2-(pyrrolidin-2-yl)thiazole-4-carboxylate
• CAS NO: 251349-56-1
• Molecular Formula: C10H15ClN2O2S
• Molecular Weight: 226.3
• Product Categories: CHIRAL CHEMICALS
• Mol File: 251349-56-1.mol

Chemical Properties

• Boiling Point: 378°C at 760 mmHg
• Flash Point: 182.4°C
• Appearance: /
• Density: 1.216
• Vapor Pressure: 4.39E-06mmHg at 25°C
• PKA: 7.95±0.10(Predicted)
• CAS DataBase Reference: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride(251349-56-1)
• EPA Substance Registry System: ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride(251349-56-1)

Safety Data

• Hazardous Substances Data: 251349-56-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride is used as a precursor in the synthesis of new drugs for various therapeutic applications. Its unique molecular structure allows it to engage with specific biological targets, making it a valuable component in the development of medications with precise mechanisms of action.
Used in Drug Discovery:
In the field of drug discovery, ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride serves as a key intermediate in the creation of novel pharmaceutical agents. Its ability to interact with receptors and enzymes suggests potential uses in treating a range of diseases, including those that require targeted therapies.
Used in Research and Development:
Ethyl 2-((R)-pyrrolidin-2-yl)thiazole-4-carboxylate hydrochloride is utilized as a research compound to explore its interactions with biological systems. This helps in understanding its potential role in medicinal chemistry and identifying new avenues for therapeutic intervention.

InChI:InChI=1/C10H14N2O2S.ClH/c1-2-14-10(13)8-6-15-9(12-8)7-4-3-5-11-7;/h6-7,11H,2-5H2,1H3;1H/t7-;/m1./s1

Upstream product

• 212009-06-8 ethyl (S)-2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)thiazole-4-carboxylate 
• 70-23-5 ethyl Bromopyruvate 
• 117175-41-4 tert‐butyl (S)‐2‐carbamothioylpyrrolidine‐1‐carboxylate 

Relevant articles and documents

Synthesis and antimicrobial activity in vitro of new amino acids and peptides containing thiazole and oxazole moieties

2-(Pyrrolidinyl)thiazole-4-carboxylic acid 5d, 2-(1-aminoalkyl)thiazole- 4-carboxamides and hydrazides 8, 10 have been synthesized using alanine, valine, and proline as educts. In addition oxazole amino acids derived from leucine 20a and alanine 20b and some peptides 13, 14, 16 containing the 5- ring heterocyclic backbone modifications have been prepared. The thiazole and oxazole containing amino acids and peptides showed moderate antibacterial activity in vitro against various Gram-positive (Staphylococcus aureus, Bacillus cereus, etc.) and Gram-negative (Escherichia coli, Proteus vulgaris, etc.) bacteria, fungi (Candida albicans), and yeast (Saccharomyces cerevisae, etc.).