117175-41-4

Basic information

• Product Name: (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 2S-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL2(R)-THIOCARBAMOYLPYRROLIDINE-1-CARBOXYLATE
• CAS NO: 117175-41-4
• Molecular Formula: C₁₀H₁₈N₂O₂S
• Molecular Weight: 230.33
• Mol File: 117175-41-4.mol
• Article Data: 23

Chemical Properties

• Melting Point: 200-201 °C
• Boiling Point: 339.5±52.0 °C(Predicted)
• Appearance: /
• Density: 1.191±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.98±0.20(Predicted)
• CAS DataBase Reference: (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(117175-41-4)
• EPA Substance Registry System: (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(117175-41-4)

Safety Data

• Hazardous Substances Data: 117175-41-4(Hazardous Substances Data)

Usage

General Description

"(R)-2-thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester" is a chemical compound with the molecular formula C10H19NO2S. It is a tert-butyl ester derivative of (R)-2-thiocarbamoyl-pyrrolidine-1-carboxylic acid, and is commonly used in organic synthesis and pharmaceutical research. (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER has been studied for its potential medical applications, and its properties make it suitable for use as an intermediate in the synthesis of various biologically active molecules. It is important to handle this chemical with care, as it may have potential health and environmental hazards if not used properly and disposed of responsibly.

Upstream product

• 70138-72-6 (R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 28310-65-8 N-tert-butyloxycarbonyl-proline p-nitrophenyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7531-52-4 L-prolinamide 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 228244-04-0 tert-butyl (2S)-2-cyanopyrrolidine-1-carboxylate 

Downstream Products

• 944030-48-2 tert-butyl (S)-2-(4-phenylthiazol-2-yl)pyrrolidine-1-carboxylate 
• 479067-56-6 (S)-4-phenyl-2-(pyrrolidin-2-yl)thiazole 
• 1310694-94-0 (S)-tert-butyl 2-(4-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)thiazol-2-yl)pyrrolidine-1-carboxylate 
• 1310694-79-1 (S)-2-(5-(4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl)thiazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1310694-78-0 (S)-tert-butyl 2-(4-(4-bromophenyl)thiazol-2-yl)pyrrolidine-1-carboxylate 
• 1005342-78-8 C₁₉H₂₁FN₂O₃S 

Relevant articles and documents

HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND

The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reducatase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.

BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY

The present invention relates to compounds of formula (I) useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.