251988-35-9Relevant articles and documents
Atom-Economical and Tandem Conversion of Nitriles to N-Methylated Amides Using Methanol and Water
Paul, Bhaskar,Maji, Milan,Kundu, Sabuj
, p. 10469 - 10476 (2019/11/05)
A cobalt complex catalyzed tandem conversion of nitrile to N-methylated amide is described using a methanol and water mixture. Using this protocol, several nitriles were directly and efficiently converted to the desired N-methylated amides. Kinetic experiments using H2O18 and CD3OD suggested that water and methanol were the source of the oxygen atom and methyl group, respectively, in the final N-methylated amides. Importantly, the participation of active Co(I)-H species in this transformation was realized from the control experiment. The kinetic isotope effect (KIE) study suggested that the activation of the C-H bond of methanol was a kinetically important step. The Hammett plot confirmed that the reaction was faster with the electron deficient nitriles. In addition, the plausible pathway for the formation of N-methylated amides from the nitriles was supported by the computational study.
Ruthenium-Catalyzed Synthesis of N-Methylated Amides using Methanol
Paul, Bhaskar,Panja, Dibyajyoti,Kundu, Sabuj
supporting information, p. 5843 - 5847 (2019/08/26)
An efficient synthesis of N-methylated amides using methanol in the presence of a ruthenium(II) catalyst is realized. Notably, applying this process, tandem C-methylation and N-methylation were achieved to synthesize α-methyl N-methylated amides. In addition, several kinetic studies and control experiments with the plausible intermediates were performed to understand this novel protocol. Furthermore, detailed computational studies were carried out to understand the mechanism of this transformation.
Catalytic hydrosilylation of carbonyl compounds by hydrido thiophenolato iron(II) complexes
Xue, Benjing,Sun, Hongjian,Niu, Qingfen,Li, Xiaoyan,Fuhr, Olaf,Fenske, Dieter
, p. 23 - 28 (2017/02/23)
The hydrosilylation of aldehydes and ketones under mild conditions with hydrido thiophenolato iron(II) complexes [cis–Fe(H)(SAr)(PMe3)4] (1–4) as catalysts is reported using (EtO)3SiH as an efficient reducing agent in the yields up to 95%. Among them complex 1 is the best catalyst. Complex 1 could also be used as catalyst to reduce the α,β-unsaturated carbonyl compounds selectively to the α,β-unsaturated alcohols in high yields.
11a-Methano-TXA compounds
-
, (2008/06/13)
The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.
